化学治疗对NSCLC血清ABCG2水平的影响  

Effect of chemotherapy on serum ABCG2 level of non-small cell lung cancer

作　　者：王大星[1] 谢彤[1] 茅乃权[1] 左传田[1] 朱波[2] 潘琪[1] 王守峰[1] 

机构地区：[1]广西医科大学附属肿瘤医院胸外科,南宁530021 [2]广西医科大学附属肿瘤医院检验科,南宁530021

出　　处：《重庆医学》2014年第35期4764-4765,4768,共3页Chongqing medicine

摘　　要：目的观察非小细胞肺癌(NSCLC)患者化学治疗前后血清乳腺癌耐药基因ABCG2水平的变化,探讨其临床意义。方法收集15例健康者和50例NSCLC患者化学治疗前后的血清,用ELISA方法检测血清中ABCG2水平,并分析其与化学治疗疗效的关系。结果 NSCLC患者化学治疗前血清ABCG2水平高于健康者(P<0.05);血清ABCG2水平与NSCLC患者TNM分期无关(P<0.05);化学治疗后血清ABCG2水平高于化学治疗前(P<0.05);化学治疗有效者化学治疗前后血清ABCG2水平差异无统计学意义(P>0.05);化学治疗无效者化学治疗后血清ABCG2水平高于化学治疗前(P<0.05);有胸水患者血清ABCG2水平高于无胸水患者,但差异无统计学意义(P>0.05)。结论 NSCLC患者血清ABCG2水平高于健康者;血清ABCG2水平可能成为预测NSCLC化学治疗疗效的有用指标。Objective To observe the change of the serum ABCG2 level of patients with non-small cell lung cancer（NSCLC）before and after chemotherapy,and explore its clinical significance.Methods Venous blood specimens of 15 healthy adults and 50 patients with NSCLC were collected before and chemotherapy,the serum ABCG2 level of these specimens were detected by ELISA.the relation between the ABCG2 level and the chemosensitivity was investigated.Results The serum ABCG2 level of patients with NSCLC before chemotherapy was significantly higher than that in healthy adults（P〈0.05）;the serum ABCG2 level was not related with TNM stage in NSCLC（P〈0.05）;The serum ABCG2 level of patients with NSCLC after chemotherapy was significantly higher than that of before（P〈0.05）;in chemosensitive patients,the different of serum ABCG2 level was not significantly before and after chemotherapy（P〉0.05）;among chemoresistant patients,the serum ABCG2 level of patients with NSCLC after chemotherapy was significantly higher than that of before（P〈0.05）;the serum ABCG2 level was higher in patients with pleural effusion than the patients without pleural effusion,but the different was not significantly（P〉0.05）.Conclusion The serum ABCG2 level of patients with NSCLC is higher than that of healthy adults;serum ABCG2 level may become a useful indicator in predicting the effect of NSCLC chemotherapy.

关 键 词：癌 非小细胞 ABCG2 酶联免疫吸附测定 化学治疗 

分 类 号：R734.2[医药卫生—肿瘤]