甲磺酸齐拉西酮与氟哌啶醇注射液治疗精神分裂症急性激越症状的对照研究  

Control study on ziprasidone versus haloperidol injection in treating acute agitation of schizophrenia

作　　者：胡光涛[1] 宋航[1] 王国威[1] 黄一[1] 陆地[1] 贺英[1] 

机构地区：[1]解放军第324医院精神卫生中心,重庆400041

出　　处：《重庆医学》2014年第35期4766-4768,共3页Chongqing medicine

摘　　要：目的比较甲磺酸齐拉西酮注射液和氟哌啶醇注射液对精神分裂症急性激越症状的疗效和安全性。方法将86例伴急性激越症状的精神分裂症患者分为观察组（n=43）和对照组（n=43）,进行随机单盲临床对照研究,观察组给予注射用甲磺酸齐拉西酮10-20mg/次肌内注射,每日总量不超过40mg;对照组给予氟哌啶醇针剂5-10mg/次肌内注射,每日总量不超过30mg。两组药物根据病情需要4-6h后可重复使用,每日注射不超过3次,疗程3d。于治疗前和治疗后2、6、24、48、72h采用阳性与阴性症状量表兴奋因子（PANSS-EC）评定激越症状,于治疗前、治疗后72h采用阳性和阴性症状量表（PANSS）、临床疗效总评量表-病情严重程度（CGI-SI）评价疗效;采用锥体外系不良反应量表（SAS）、药物不良反应量表（TESS）、实验室检查评价不良反应。结果与治疗前比较,观察组在治疗后2hPANSS-EC评分即显著降低,其他各观察点PANSS总分、PANSS-EC评分及CGI-SI评分均显著下降（P〈0.01）;但观察组和对照组组间差异无统计学意义（P〉0.05）。两组临床总有效率差异无统计学意义（P〉0.05）。两组均未出现严重不良事件,观察组药物不良反应发生率为37.21%,显著低于对照组的53.49%（P〈0.05）。结论注射用甲磺酸齐拉西酮能有效治疗精神分裂症患者急性激越症状,疗效与氟哌啶醇相当,不良反应发生率更低,安全性好。Objective To compare the curative effect and safety between ziprasidone injection and haloperidol injection in the treatment of acute agitation of schizophrenia.Methods Totally 86 patients with acute agitation of schizophrenia were divided into observational group（n=43）and control group（n=43）,the study used a random,single-blinded and clinical controlled experiment.the observational group was given ziprasidone mesylate 10-20 mg every time by intramuscular injection and the amount was less than 40 mg every day;control group was given haloperidol injection 5-10 mg every time by intramuscular injection and the amount was less than 30 mg every day.Drugs in the two groups could be repeated according to the state of illness after 4-6hours,and the daily injections were no more than 3times and the course of treatment was 3days.The Positive and Negative Symptoms Scale Excited Factor（PANSS-EC）was used to evaluate the agitated symptoms before treatment and 2,6,24,48,72 hours after treatment,the Positive and Negative Symptoms Scale（PANSS）and Clinical Global Impression Scale-Severity of Illness（CGI-SI）was used to evaluate the curative effect;extrapyramidal side adverse reaction（SAS）,Treatment Emergent Symptoms Scale（TESS）and the related lab tests were employed to assess the adverse reaction.Results Comparing with the baseline,PANSS-EC score of observe group decreased significantly at 2hafter the treatment;at other observation time-points,PANSS scores,PANSS-EC scores and CGI-SI scores in the two groups both decreased significantly（P〈0.01）;but with no significant difference between the two groups（P〉0.05）.There were no significant difference in the total effective rate between the two groups（P〉0.05）.There were no serious adverse events in the two groups.incidences of adverse reactions of observe group were 37.21%,which were significantly lower than that of control group 53.49%（P〈0.05）.Conclusion Effect of ziprasidone injection and haloperidol injection was comparable in the tre

关 键 词：精神分裂症 齐拉西酮 氟哌啶醇 兴奋激越 

分 类 号：R749.3[医药卫生—神经病学与精神病学]