L-苯丙氨酸脲类化合物的合成工艺改进  

Process Improvement on Synthesis of L-phenylalanine Derivatives

作　　者：高玉华[1] 乐文俊[1] 程贺龙[1] 陆鸿飞[1] 

机构地区：[1]江苏科技大学生物与化学工程学院,江苏镇江212003

出　　处：《合成化学》2014年第6期807-809,共3页Chinese Journal of Synthetic Chemistry

基　　金：国家自然科学基金资助项目(21201087)

摘　　要：以L-苯丙氨酸为原料,经甲酯化反应制得中间体丙谷胺酸甲酯盐酸盐(1);以三乙胺为缚酸剂,1经固体光气活化制得苯丙氨酸异氰酸酯后,再分别与伯胺反应合成了4个苯丙氨酸脲类化合物(3a^3d),收率90.7%~94.2%,其结构经1H NMR,MS和X-衍射确证。An intermediate,1-methoxy-1-oxo-3-phenylpropan-2-aminium chloride（ 1）,was prepared by methyl-esterification of L-phenylalanine. Four L-phenylalanine Derivatives in yield of 90. 7% -94. 2 were synthesized by activation of 1 via triphosgene,using triethylamine as the acid acceptor,and then reacted with primary amine. The structures were confirmed by^1 H NMR,MS and X-ray diffraction.

关 键 词：L-苯丙氨酸 脲类化合物 合成 工艺改进 

分 类 号：O623.73[理学—有机化学] O621.3[理学—化学]