丁卡因胶浆用于宫颈癌三维图像引导下近距离治疗的临床观察  

The Clinical Effect of Tetracaine Mucilage Used in 3D Image-guided Brachytherapy for Cervical Carcinoma

作　　者：江庆华[1] 李华春[1] 曾万琴[1] 杨芮[1] 李彬[1] 张丹[1] 

机构地区：[1]四川省肿瘤医院,成都610041

出　　处：《肿瘤预防与治疗》2014年第6期272-275,共4页Journal of Cancer Control And Treatment

摘　　要：目的:探讨丁卡因胶浆外用在宫颈癌三维图像引导近距离治疗中的镇痛效果及对阴道损伤的影响。方法:选择行宫颈癌三维图像引导近距离治疗患者80例,随机分为实验组40例和对照组40例,实验组在探测宫腔深度及放置施源器前均使用盐酸丁卡因胶浆行阴道黏膜及宫颈黏膜的表面麻醉,对照组仅采用常规探腔及放置施源器,观察两组患者治疗的疼痛反应及阴道损伤情况。结果:实验组和对照组疼痛总发生率分别为72.5%、92.5%,实验组的疼痛发生率明显低于对照组(P=0.037)。实验组和对照组阴道损伤总发生率分别为32.5%、67.5%,实验组的阴道损伤发生率明显低于对照组(P=0.003)。此外,实验组的轻度、中度、重度疼痛的发生率均低于对照组,实验组的Ⅱ级、Ⅲ级、Ⅳ级阴道损伤的发生率均低于对照组。结论:在宫颈癌三维图像引导近距离治疗时使用盐酸丁卡因胶浆行阴道及宫颈黏膜的表面麻醉,能明显缓解治疗中的疼痛,降低阴道损伤的发生率及损伤的程度,减轻患者痛苦,可临床推广应用。Objective： To assess the analgesic effect and vagina injury alleviation of Tetracaine Mucilage used in 3D image-guided brachytherapy for cervical carcinoma. Methods：Eighty patients of cervical carcinoma in need of brachy-therapy were randomized into two groups, 40 in experimental group and 40 in control group. Tetracaine Mucilage was used as topical anesthesia in site of vaginal and cervical mucosa in experimental group before brachytherapy with no use in control group. Results：The incidence of pain and vagina injury was 72. 5% vs 92. 5% （P=0. 037） and 32. 5% vs 67. 5% （P=0. 003） for experimental group and control group respectively. Furthermore, the incidence of mild, moderate, severe pain and Grade II,III,IVvagina injury in experimental group were less than those in control group. Conclusion：The use of Tet-racaine Mucilage in 3D image-guided brachytherapy exerts positive effects in terms of pain alleviation and reducing vagina injury, leading to more effective treatment.

关 键 词：丁卡因 宫颈癌 三维图像引导下近距离治疗 镇痛 阴道损伤 

分 类 号：R737.33[医药卫生—肿瘤] R730.55[医药卫生—临床医学]