酶法转化制备人参皂苷单体的研究进展  

Research progress on enzymatic conversion for preparing individual ginsenosides

作　　者：姬庆[1] 郜玉钢[1] 赵岩[1] 何忠梅[1] 臧埔 张连学[1] 

机构地区：[1]吉林农业大学中药材学院,吉林长春130118

出　　处：《中草药》2014年第22期3356-3360,共5页Chinese Traditional and Herbal Drugs

基　　金：吉林省基础研究项目(20130102075JC);国家科技支撑计划项目(2011BAI03B010602);国家科技重大专项子课题(2012ZX09304006);吉林省科技厅重点项目(20110228);吉林省科技条件与平台建设计划(20112101);吉林省现代农业产业技术体系建设项目(201218)

摘　　要：人参皂苷具有抗肿瘤、抗病毒、延缓衰老、增强免疫等多种药理活性,但不同皂苷单体在药材及其提取物中量不同,其药理活性亦有差异,量低而药理活性强的皂苷单体需大量制备,以满足医疗和科研需要。如何定向提高人参皂苷单体的量,酶法制备是解决该问题的关键技术,且利用该法有效定向获得人参皂苷单体进行了大量研究。就酶法转化制备人参皂苷单体进行综述,为人参皂苷单体的进一步开发利用提供理论依据和参考。Ginsenosides have antitumor, antiviral, anti-aging, immune enhancement, and other pharmacological activities, but the contents of different individual ginsenosides in herbs and their extracts are different and their pharmacological activities are different. A lot of individual ginsenosides with low contents and strong pharmacological activities are required and prepared to meet the medicinal and scientific needs. To directly improve the contents of individual ginsenosides, enzymatic preparation is a key technology. The extensive research was conducted to obtain the effective individual ginsenosides directly by enzymatic conversion. In this paper, the enzymatic conversion for preparing individual ginscnosides is reviewed to provide a theoretical basis and reference for the further development and utilization of individual ginsenosides.

关 键 词：酶法 人参皂苷 生物转化 人参皂苷RG1 人参皂苷RG3 

分 类 号：R282.1[医药卫生—中药学]