虎杖改善阿尔茨海默病小鼠模型的学习记忆能力及作用机制研究  

Effects and mechanism on learning and memory of giant knotweed in AD model mice

作　　者：朱伟[1] 李志[2] 张丹[1] 

机构地区：[1]泸州医学院药学院,泸州646000 [2]泸州医学院附属中医院

出　　处：《陕西医学杂志》2014年第12期1574-1575,1581,共3页Shaanxi Medical Journal

基　　金：四川省教育厅项目(No 2011-103)

摘　　要：目的：观察虎杖醇提物、水提物对阿尔茨海默病小鼠模型学习记忆能力的影响,并初步探讨其作用机制。方法：采用侧脑室注射β-淀粉样蛋白片段1-42（Aβ1-42）建立AD小鼠模型,通过Morris水迷宫实验检测小鼠学习记忆能力,使用试剂盒检测小鼠脑组织总抗氧化能力、乙酰胆碱酯酶活性、丙二醛和一氧化氮含量。结果：虎杖醇提物、水提物均不同程度地改善模型小鼠的学习记忆能力,提高总抗氧化能力,以醇提物效果更好,醇提物还能抑制乙酰胆碱酯酶活性,降低丙二醛和一氧化氮含量。结论：虎杖能改善Aβ致AD小鼠模型的学习记忆能力,其作用机制可能与抗氧化、减少炎症介质的产生和调节胆碱能系统等多方面综合作用有关。Objective：To observe the influence of giant knotweed on learning and memory in AD model mice,discuss about improving learning and memory mechanisms.Methods：The mice Alzheimer＇s Disease model was developed by injecting Aβ1-42into lateral ventricle.By Morris water maze test,observe the effect on learning and memory ability,testtotal antioxidant capacity,the content of MDA,AChE and NO in brain.Results：In treating groups by giant knotweed,the ability of learning and memorizing were improved,total antioxidant capacity was increased,MDA was decreased and the content of Ache and NO were reduced.Conclusion：Giant knotweed has protective effects on AD mice induced by Aβ,its mechanisms are probably owning to antioxidation and inhibiting the activity of AChE and NO.

关 键 词：阿尔茨海默病/治疗 学习障碍 @虎杖 动物 实验 小鼠 

分 类 号：R749.1[医药卫生—神经病学与精神病学]