石墨烯凝胶对咖啡因的缓释作用  

Application of graphene gel in drug sustained-release material

作　　者：黄丹灵[1] 郑龙珍[1] 邹志君[1] 纪忆[1] 董泽民[1] 亢晓卫 

机构地区：[1]华东交通大学化学化工系,南昌330013

出　　处：《化工新型材料》2014年第12期208-210,共3页New Chemical Materials

基　　金：国家自然科学基金(20965003)

摘　　要：用Hummers法合成氧化石墨烯(GO),再加入亚硫酸氢钠制得石墨烯凝胶(GNG),并应用于药物缓释领域。以咖啡因作为模型药物,探讨不同pH值条件下GNG对咖啡因的缓释效果。结果表明,GNG的吸水率约为140%,载药量约为1.5g/g,咖啡因在模拟胃液中的累积释放量较小且释放速率较慢,在模拟肠液中释放量较大且释放速率较快,体现了良好的pH敏感控制释放性能。Graphene gel（GNG）was prepared by adding sodium hydrogen sulfite into graphene oxide（GO）which was synthetized by Hummers method,and then applied to drug sustained-release material.Caffeine was used as model medicine,and then the release behavior from GNG in different pH condition was research.It indicated that the water absorption was about 140% and the loading amount of drug was about 1.5g/g.In simulation test showed that the amount and rate of drug release from GNG was low in simulated gastric fluid,while it was high in simulated intestinal fluid.

关 键 词：石墨烯凝胶 药物缓释 咖啡因 PH敏感 

分 类 号：O613.71[理学—无机化学] TQ460.1[理学—化学]