血小板参数、NIHSS评分与中国缺血性卒中亚型分型的关系  

The relationship between platelet parameters,the scores of NIHSS and CISS subtypes of acute cerebral infarction

作　　者：姜源[1] 董玉霞[2] 刘晓楠[1] 李慧源[1] 宋静静[1] 孙晓红[1] 

机构地区：[1]中国医科大学附属第四医院神经内科,辽宁沈阳110031 [2]中国医科大学附属盛京医院抚顺医院神经内科,辽宁抚顺113001

出　　处：《中国临床研究》2014年第12期1448-1450,1454,共4页Chinese Journal of Clinical Research

基　　金：辽宁省科学技术计划项目(2013225049)

摘　　要：目的探讨血小板参数、NIHSS评分与中国缺血性卒中亚型(CISS)分型中大动脉粥样硬化性(LAA)及穿支动脉病变(PAD)的关系。方法 2012年1月至2014年5月急性脑梗死住院患者213例。依据临床症状、体征、头颅核磁共振、头颈部CTA、颈动脉超声、脑血管造影结果分为LAA组(113例)、PAD组(100例)。均进行血小板检测,参数包括血小板计数(PLT)、平均血小板体积(MPV)、血小板体积分布宽度(PDW)、血小板比积(PCT),记录入出院时NIHSS评分,并进行比较。结果与PAD组比较,LAA组PLT和PCT明显减少(P均<0.05);PDW和MPV略升高,差异均无统计学意义(P均>0.05)。两组PLT与MPV、PDW呈负相关(r=-0.181,r=-0.329,P均<0.01),PLT与PCT呈正相关(r=0.926,P<0.01)。入院时LAA组NIHSS评分高于PAD组(P<0.01);出院时LAA组NIHSS评分高于PAD组,但差异无统计学意义(P>0.05)。两组患者入院时NIHSS评分与PLT、MPV、PDW、PCT均无相关性(r=0.000,r=0.128,r=0.118,r=0.042,P均>0.05),出院时NIHSS评分与MPV、PDW呈正相关(r=0.160,r=0.146,P均<0.05),与PLT、PCT无相关性(r=-0.005,r=0.042,P均>0.05)。结论血小板参数、NIHSS评分与CISS分型LAA及PAD关系密切,对疾病的疗效、预防及判断预后具有重要的参考价值。To explore the relationship between platelet parameters, the scores of national institutes of health stroke scale （NIHSS） and large artery atherosclerosis （LAA） subtype, penetrating artery disease （PAD） subtype according to Chinese ischemic stroke subclassification （CISS） of acute cerebral infarction. Methods A total of 213 patients with acute cerebral infarction admitted between January 2012 and May 2014 were included in this study. On the basis of clinical symptoms, signs, head magnetic resonance, head and neck computed tomographic angiography （ CTA）, carotid artery ultrasound, cerebral angiography, the patients were divided into LAA group （n = 113）and PAD group（ n = 100）. The platelet count （PLT）, mean platelet volume （MPV）, platelet volume distribution width （PDW） and plateletcrit （PCT） were detected in all patients, and the NIHSS scores at admission and discharge were recorded and compared. Results Compared with PAD group, PLT and PCT decreased significantly （ all P 〈 0.05）, and PDW and MPV slightly increased without statistical significance （ P 〉 0.05 ） in LAA group. In two groups, the PLT was negatively correlated with the MPV and PDW, respectively （r = -0. 181, r = -0.329, all P 〈 0.01 ） and was positively correlated with the PCT （r =0. 926, P 〈0.01 ）. Compared with PAD group, the NIHSS score at admission in LAA group increased significantly （P 〈0.01 ）, and it at discharge remained slightly increased without statistical significance （P 〉 0. 05 ）. In two groups, NIHSS scores at admission were all not correlated with PLT, MPV, PDW and PCT, respectively （ r = 0. 000,r =0. 128, r =0. 118, r = 0.042, all P 〉 0.05）, while the scores at discharge were positively correlated with MPV and PDW, respectively （ r = 0. 160, r = 0. 146, all P 〈 0.05 ）, but not correlated with PLT, PCT （ r = - 0.005, r = 0.042, all P 〉 0.05）. Conclusions The platelet parameters and the NIHSS scores are associated with LAA and PAD subtypes of

关 键 词：脑梗死 血小板计数 平均血小板体积 血小板体积分布宽度 血小板比积 卒中量表评分 中国缺血性卒中亚型 

分 类 号：R743.3[医药卫生—神经病学与精神病学]