酒精相关的韦尼克脑病与柯萨科夫综合征  

Alcohol related Wernicke's encephalopathy and Korsakov's syndrome

作　　者：杨雪[1] 盛利霞[1] 郝伟[2] 汤宜朗[1,3] 

机构地区：[1]首都医科大学附属北京安定医院,北京100088 [2]中南大学湘雅医院精神卫生研究所,长沙市410011 [3]Emory University School of Medicine Atlanta,usa30322

出　　处：《中国药物滥用防治杂志》2014年第6期368-372,共5页Chinese Journal of Drug Abuse Prevention and Treatment

摘　　要：目的:介绍韦尼克脑病(WE)与柯萨科夫综合征(KS)的病因、发病机制、临床表现、诊断要点及治疗方法。方法:对近年文献进行复习。结果:WE和KS属于统一疾病的不同过程,二者均是由维生素B1缺乏所致。临床上最常见的原因仍为长期大量饮酒。前者为急性期,大多可逆;后者则难以逆转。WE常常应漏诊而延误治疗,传统的诊断标准往往难以发现早期病例。绝大多数病例可通过及时、充分补充维生素B1使疾病好转。结论:对于有酒精滥用或依赖患者,一旦怀疑WE,即应及时、充分补充维生素B1。Objective： To review the updates on the causes,mechanism,clinical features and treatment of Wernicke＇s encephalopathy（ WE） and Korsakoff Syndrome（ KS）. Methods： Review of literature on this topic. Results： WE and KS each represents a different stage of the disease caused by thiamin（ vitamin B1） deficiency. The most common cause is alcohol abuse. We represents the acute phase and reversible in most cases,while KS is irreversible. Misdiagnosis in WE is common and often lead to inadequate treatment,the traditional diagnostic criteria often fail to detect early cases. Timely and adequate thiamine treatment can reverse most cases.Conclusion： For patients with alcohol abuse or alcohol dependence,once suspected with WE,thiamine should be given at once and at an adequate dose.

关 键 词：韦尼克脑病 柯萨可夫综合症 维生素B1 临床表现 诊断 治疗 

分 类 号：R749.62[医药卫生—神经病学与精神病学]