一种多组分合成2-亚胺基噻唑啉衍生物的新方法  

A Novel Synthesis of Thiazol-2-imines via a Multicomponent Reaction

作　　者：黄艺伟[1] 郎勃[1] 贾建洪[1] 岳斌杰[1] 单尚[1] 金红卫[1] 

机构地区：[1]浙江工业大学化学工程学院,浙江杭州310014

出　　处：《浙江化工》2014年第12期12-15,共4页Zhejiang Chemical Industry

基　　金：浙江省重点科技创新团队项目(2010R50018)

摘　　要：以伯胺、异硫氰酸酯和炔丙基溴为原料,在磷酸钾作用下,采用"一锅法"反应合成2-亚胺基噻唑啉衍生物。该方法具有原料易得,步骤简单,产率较高等优点,为合成2-亚胺基噻唑啉类化合物提供了一种实用的新方法。所得化合物的结构均经核磁和质谱确证。An efficient one-pot synthesis of thiazol-2-imine derivatives from primary amine,isocyanate and propargyl bromide had been developed. The procedure was mediated by potassium phosphate. This method has some advantages,such as readily available raw materials,easy of operation,and high yields. Thus,a novel method for the synthesis of thiazol-2-imine compounds was developed. The structures of the product were characterized by NMR and MS.

关 键 词：炔丙基溴 多组分反应 一锅法 2-亚胺基噻唑啉 

分 类 号：TQ463.5[化学工程—制药化工]