用于脑水肿检测的开放式核磁共振系统设计  

Design of Open Nuclear Magnetic Resonance System for Brain Edema Detection

作　　者：李春莉[1] 何为[1] 杨帆[1] 何晓龙[1] 高兵[1] 

机构地区：[1]重庆大学电气工程学院输配电装备及系统安全与新技术国家重点实验室,重庆400030

出　　处：《高电压技术》2014年第12期3846-3853,共8页High Voltage Engineering

基　　金：国家自然科学基金(513777186)~~

摘　　要：颅内含水体积的变化情况能够直接反映脑水肿病情的严重程度。为此,设计了用于检测脑水肿的开放式核磁共振(ONMR)系统,通过检测目标区域不同深度物体的核磁共振(NMR)信号和被测物在不同含水体积情况下的核磁共振信号,来检测头颅中不同位置的含水体积。首先描述了系统中主磁体的设计模型、射频(RF)线圈的优化选择,其次制作了螺线型线圈印刷电路板(PCB)模型和电容匹配电路,搭建了开放式核磁共振系统,最后以位于磁体目标区域不同深度位置的橡皮和不同含水体积的面粉为样品,用实验验证了系统的可靠性和准确性。实验结果表明所设计的系统能够用来检测被测物体中不同位置的含水体积情况,进而可以用于脑水肿的实时检测。整个系统具有便携性、小型化、价格低廉的优点,可以为开放式核磁共振仪进一步应用于临床提供实验支撑。Change of aqueous volume in brain directly reflects the severity of cerebral edema. Hence, we designed an open nuclear magnetic resonance（NMR） system for brain edema detection. The system can detect the aqueous volume in different positions in head by measuring the NMR signals of objects with different aqueous volumes at different depths in target area. After demonstrating the optimal selections of main magnet and radio frequency（RF） coil, we made a PCB model of spiral coil and its capacitor matching circuit, and then built an open NMR system. Using rubbers at different depths and flour with various aqueous volumes in magnet target area as the samples, we proved the NMR system＇s reliability and accuracy through experiments. Based on the experiment results, it is concluded that the proposed system can detect aqueous volume distribution at different positions in target object, and consequently for real-time detection of cerebral edema. Due to the system＇s portability, miniaturization and low cost, it strongly supports the further application of open NMR instrument in clinical.

关 键 词：主磁体 射频线圈 优化选择 开放式核磁共振系统 脑水肿 颅内含水体积 

分 类 号：R742[医药卫生—神经病学与精神病学]