α突触核蛋白与神经系统疾病的关系研究进展  

Research Progress inα-Synuclein Relationship with Diseases of the Nervous System

作　　者：马京京[1] 李海涛[2] 张小宁[3] 

机构地区：[1]新疆医科大学研究生院,乌鲁木齐830000 [2]新疆医科大学第二附属医院神经内科,乌鲁木齐830000 [3]新疆医科大学第一附属医院神经内科,乌鲁木齐830000

出　　处：《医学综述》2014年第24期4422-4424,共3页Medical Recapitulate

基　　金：新疆维吾尔自治区自然科学基金(2011211A063)

摘　　要：α突触核蛋白(α-Syn)是一种小分子酸性可溶性蛋白,是帕金森病(PD)发病的病理基础,在PD的发生中起重要作用。该文对α-Syn的结构、功能及其导致PD的发病机制等方面进行了综述,结合近年来对遗传性脊髓小脑型共济失调2型(SCA2)与α-Syn关系的研究来阐述带有PD症状的SCA2的发病是否与PD有共同的发病基础,是否也是α-Syn异常聚集所致,尚待进一步考证。α-synuelein（ct-Syn） is a small molecule acid soluble proteins, the pathologacal basis ot the onset of Parkinson disease, playing an important role in the genesis of Parkinson disease. Here is to make a review of the α-synuelein＇s structure, function and role in the pathogenesis of Parkinson disease, combined with recent research on the correlation between hereditary spinocerebellar ataxia 2 （ SCA2 ） and α-synaptie nuclear protein, to illustrate whether SCA2 has a common onset basis with Parkinson disease, whether it is also caused by abnormal aggregation of α-synuelein due.

关 键 词：Α突触核蛋白 帕金森病 脊髓小脑共济失调2型 

分 类 号：R741[医药卫生—神经病学与精神病学]