前列腺慢性炎症与前列腺癌  

Chronic Inflammation of the Prostate and Prostate Cancer

作　　者：岳亮[1] 郝振文[1] 马志方[2] 

机构地区：[1]山西医科大学第一临床医学院泌尿外科,太原030001 [2]山西医科大学第一医院泌尿外科,太原030001

出　　处：《医学综述》2014年第24期4466-4468,共3页Medical Recapitulate

基　　金：山西省卫生厅科技攻关项目(2011027)

摘　　要：前列腺癌组织中除肿瘤细胞外还存在多种大量炎性细胞,如肥大细胞、巨噬细胞、中性粒细胞等,这些炎性细胞可分泌多种细胞因子,促进炎性细胞聚集,而大量炎性细胞聚集后也可分泌蛋白溶解酶和细胞因子,这些细胞因子通过多种信号通路可刺激前列腺癌细胞生长、血管和淋巴管生成及肿瘤的浸润转移。雄激素受体在此过程中也发挥着举足轻重的作用。该文将对前列腺慢性炎症与前列腺癌的关系予以介绍。Besides a large number of tumor cells, there is a variety of inflammatory cells such as mast cells, macrephages, ueutrephils, etc. existing in prostate cancer tissues, which can secrete a variety of cytokines, and promote the accumulation of inflammatory cells which could also secrete proteolytic enzymes and cytokines. And these cytokines can stimulate the growth of prostate cancer cells, blood vessels, lymphangiogenesis and the invasion and metastasis of tumor via multiple signaling pathways. Androgen receptor also plays a pivotal role in this process. Here is to make a review of the relationships between chronic inflammation of the prostate and prostate cancer.

关 键 词：前列腺炎 前列腺肿瘤 受体 雄激素 

分 类 号：R737.25[医药卫生—肿瘤]