口腔鳞癌组织中p73、p15蛋白的表达变化及意义  

Expression and significance of p73 and p15 protein in oral lichen planus and oral squamous cell carcinoma

作　　者：傅琨[1] 谢镇春[1] 周志迎 

机构地区：[1]广东医学院附属医院,广东湛江524000 [2]暨南大学华侨医院

出　　处：《山东医药》2014年第47期25-27,共3页Shandong Medical Journal

基　　金：湛江市科技攻关计划项目(2011C3109022)

摘　　要：目的观察口腔鳞癌组织中p73、p15蛋白的表达变化,并探讨其意义。方法采用免疫组化SP法检测20例份口腔正常黏膜组织(对照组)、35例份扁平苔藓组织(扁平苔藓组)、50例份鳞癌组织(鳞癌组)中p73、p15蛋白,并分析鳞癌组中两指标的相关性。结果鳞癌组、扁平苔藓组、对照组p73阳性率分别为82.00%、54.29%、15.00%,p15阳性率分别为42.00%、100.00%、100.00%,两两比较,P均<0.05;鳞癌组Ⅰ、Ⅱ、Ⅲ级p73阳性率分别为70.83%、90.00%、100.00%,p15阳性率分别为54.17%、35.00%、16.67%,两两比较,P均<0.05。鳞癌组p73、p15蛋白表达呈负相关(r=-0.932,P<0.05)。结论口腔鳞癌组织中p73蛋白表达升高,p15蛋白表达降低,两者在口腔鳞癌发生、发展过程当中起到相互拮抗的作用。Objective To investigate the expression and significance of p 73 and p15 protein in oral squamous cell car-cinoma.Methods Used immunohistochemical SP method to detect p 73, p15 protein from 20 cases of normal oral mucosa parts （control group）, 35 cases parts of lichen planus （OLP group）, 50 cases of squamous cell parts （SCC group）, and we analyzed the relationship of two indicators of SCC group .Results The control group, OLP group, and SCC group′s p73 posi-tive expression rates were respectively 82.00%, 54.29%and 15.00%.The three groups′p15 positive expression rates re-spectively were respectively 42.00%, 100.00%and 100.00%, and after pairwise comparisons , all P＆lt;0.05.Ⅰ,Ⅱ,Ⅲgrade squamous positive rates of p73 in SCC group were 70.83%, 90.00%and 100.00%, and p15-positive rates were 54.17%, 35.00%and 16.67%, and after pairwise comparisons , all P＆lt;0.05.p73 and p15 protein expression were negatively correla-ted（r=-0.932, P＆lt;0.05） in SCC group.Conclusion In oral squamous cell carcinoma , p73 protein expression value in-crease, and p15 protein expression value reduce .They play the role of mutual antagonism in the development of oral squa-mous cell carcinoma .

关 键 词：P73蛋白 P15蛋白 口腔扁平苔藓 口腔鳞癌 

分 类 号：R780.2[医药卫生—口腔医学]