黑果枸杞水提取液对小鼠耐常压缺氧能力的影响  

EFFECT OF LYCIUM RUTHENICUM MURR WATER EXTRACT ON HYPOXIA AT NORMAL PRESSURE TOLERANCE

作　　者：段雅彬 朱俊博[1] 姚星辰[1] 陈湘宏[1] 瞿述根 张娟玲[1] 李向阳[1] 

机构地区：[1]青海大学医学院,青海西宁810001

出　　处：《青海医学院学报》2014年第4期264-267,共4页Journal of Qinghai Medical College

基　　金：青海省自然科学基金资助项目(2013-Z-909);教育部新世纪优秀人才支持计划(NCET-10-0917)

摘　　要：目的探讨黑果枸杞水提取液对小鼠耐常压缺氧能力的影响。方法将SPF级小鼠分为空白对照组,阳性组,黑果枸杞高、中、低剂量组,灌胃给药14 d后进行常压密闭缺氧实验,观察各组小鼠存活时间、血红蛋白数量、红细胞数量、一氧化氮含量和抗氧化酶活力、脑含水量的变化。结果中低剂量黑果枸杞水提取液能增加常压缺氧小鼠的存活时间、降低脑含水量。对HGB、RBC、GSH-PX、CAT无明显影响。结论黑果枸杞水提取液对常压缺氧小鼠有一定保护作用。Objective To investigate the effect of the Lycium ruthenicum Murr Water extract on hypoxia at nor- mal pressure tolerance. Methods SPF mice were divided into control group, positive group and Lycium ruthenicum Murr Water extract group. The later further divided into three sub - groups, eg. high, middle and low does groups （LH, LM, LL）. Lycium ruthenicum Murr Water extract was fed for 14 days in mice and then hypoxia at normal pres- sure to observe the hemogramand RBC, the NO content, the the activity of anti - oxidation enzyme and the brain wa- ter content. Results Lycium ruthenicum Murr Water extract could significantly increase the survival time in mice, as well as reduce the brain water content, while the HGB, RBC, CAT, GSH - PX, T - AOC showed no significant statis- tical difference. Conclusion The results show that Lycium ruthenicum Murr Water extract has the effects of anti - hy- poxia protecting the mice in hypoxic condition at normal pressure.

关 键 词：黑果枸杞 抗缺氧 清除自由基 

分 类 号：R285[医药卫生—中药学]