羊水过多产前诊断及妊娠结局分析  

Analysis on prenatal diagnosis and pregnancy outcome of polyhydramnios

作　　者：刘俐伶[1] 邓碧叶 庞丽红[1] 邓丽[1] 殷艳[1] 

机构地区：[1]广西医科大学第一附属医院妇产科,广西南宁530021

出　　处：《中国妇幼保健》2015年第2期239-241,共3页Maternal and Child Health Care of China

基　　金：广西自然科学基金〔2014GXNSFAA118246〕;广西卫生厅自筹基金项目〔Z2014042〕

摘　　要：目的：通过对妊娠期羊水过多的孕妇进行产前诊断及妊娠结局分析,探讨羊水过多的病因及妊娠结局情况。方法：选取2008年7月~2013年7月在广西医科大学第一附属医院产前诊断中心就诊的孕17~32周的50例羊水过多孕妇为病例组,同期羊水量正常孕妇80例为对照组。分析羊水过多的病因,对羊水过多孕妇行羊水或脐带血胎儿染色体核型分析,并对地中海贫血基因携带者行羊水或脐带血基因分析,随访记录及分析比较两组的妊娠结局。结果：病例组羊水过多的病因中,不明原因占44.0%,染色体异常占4.0%,重型α地中海贫血占14.0%,胎儿畸形占30.0%,母胎疾病占8.0%。与对照组相比,病例组的剖宫产率、早产率、胎儿畸形率、胎儿窘迫率、巨大胎儿发生率及胎儿为女性比率均增高,差异有统计学意义（P〈0.05）。结论：羊水过多与胎儿畸形、胎儿染色体异常和胎儿重型α地中海贫血有一定关系,但仍有约1/3病例病因不明;羊水过多的妊娠结局较差,有必要对羊水过多孕妇加强孕期母胎监测及进行胎儿产前诊断。Objective： To analyze prenatal diagnosis and pregnancy outcome of polyhydramnios, explore the causes and pregnancy outcome of pregnant women with polyhydramnios. Methods ： Fifty pregnant women with polyhydramnios of 17 - 32 gestational weeks were se- lected from prenatal diagnosis center of this hospital from July 2008 to July 2013 as ease group; eighty pregnant women with normal amniotie fluid volume were selected as control group during the same period. The causes of polyhydramnios were analyzed, chromosomal karyotyping of amniotie fluid or fetal umbilical cord blood was conducted, amniotic fluid or fetal umbilical cord blood gene analysis was conducted among the pregnant women carrying thalassemia gene ; pregnancy outcomes in the two groups were followed up, recorded and compared. Results： A- mong the pregnant women with polyhydramnios in case group, the pregnant women with unknown causes accounted for 44. 0% , 4. 0% of the pregnant women were found with chromosomal abnormalities, 14. 0% of the pregnant women were found with severe α- thalassemia, 30.0% of the pregnant women were found with fetal malformations, and 8.0% of the pregnant women were found with maternal - fetal diseases. The rates of cesarean section, preterm birth, fetal malformation, fetal distress, macrosomia and female fetus in case group were statistically signif- icantly higher than those in control group （ P 〈 0. 05） . Conclusion ： Polyhydramnios is correlated with fetal abnormalities, fetal chromosom- al abnormalities and fetal severe α- thalassemia to a certain extent, but there are still about 1/3 of the pregnant women with unknown cau- ses; the pregnancy outcome of pregnant women with polyhydramnios is poor, it is necessary to take maternal - fetal monitoring and fetal pre- natal diagnosis for pregnant women with polyhydramnios.

关 键 词：羊水过多 产前诊断 妊娠结局 

分 类 号：R714.12[医药卫生—妇产科学]