新疆地区维吾尔族、汉族癫痫患儿拉莫三嗪血药浓度对比分析  

Analysis of the Differences of the Serum Concentration of Lamotrigine Between Children of Uygur and Han Nationality with Epilepsy in Xinjiang

作　　者：贾莉[1] 周明明[1] 李红健[1] 蒋玉凤[1] 于爱平[1] 

机构地区：[1]新疆维吾尔自治区人民医院,新疆乌鲁木齐830001

出　　处：《儿科药学杂志》2015年第1期34-36,共3页Journal of Pediatric Pharmacy

基　　金：第一届紫禁城药师国际论坛科研课题

摘　　要：目的：探讨新疆地区维吾尔族、汉族癫痫患儿拉莫三嗪血药浓度是否存在差异。方法：采用高效液相色谱法（HPLC）对60例服用拉莫三嗪的癫痫患儿进行拉莫三嗪血清稳态药物浓度测定,分析其血药浓度与族别的关系。结果：在推荐剂量1~5mg/（kg·d）范围内,相同条件下,不同族别组患儿拉莫三嗪血清药物浓度比较差异无统计学意义（P〉0.05）。结论：在推荐剂量范围内,新疆地区维吾尔族、汉族癫痫患儿拉莫三嗪血清药物浓度与族别无相关性。Objective： To study the differences of the serum concentration of lamotrigine between children of Uygur and Han nationality with epilepsy in Xinjiang. Methods： Totally 60 children with epilepsy were collected from our hospital, each of them was treated by lamotrigine. The concentration of lamotrigine in serum was detected by high-performance liquid chromatography （ HPLC ） method. Results： In recommended dose, the concentration of lamotrigine of Han nationality is little higher than that of Uygur, and showing no significant difference （P〉0.05）. Conclusion： In recommended dose, the concentration of lamotrigine had no correlation with Uygur or Han nationality.

关 键 词：拉莫三嗪 血药浓度 癫痫患儿 维吾尔族 汉族 

分 类 号：R742.1[医药卫生—神经病学与精神病学]