局部晚期鼻咽癌调强放疗远期疗效分析  

Long-term results in locally advanced nasopharyngeal carcinoma treated by intensity-modulated radiotherapy

作　　者：张典刚[1] 黄莉[1] 耿晓涛[1] 王若峥[1,2] 

机构地区：[1]新疆医科大学附属肿瘤医院放疗中心,乌鲁木齐830011 [2]新疆医科大学新疆肿瘤学重点实验室,乌鲁木齐830011

出　　处：《新疆医科大学学报》2015年第1期17-20,25,共5页Journal of Xinjiang Medical University

基　　金：新疆维吾尔自治区国际合作项目(201141138);国家自然科学基金(81160327);乌鲁木齐市人才工程重点培养对象专项基金(P112310001)

摘　　要：目的评价调强放射治疗局部晚期鼻咽癌的远期疗效。方法对2008年1—12月在新疆医科大学附属肿瘤医院接受放射治疗并完成根治剂量、疗前及疗中无远处转移证据且临床分期为Ⅲ期及Ⅳa期的56例鼻咽癌患者的临床资料进行回顾性分析。采用同步推量调强放射治疗技术治疗,观察远期疗效及其影响因素。结果随访率为94.6%,5年总生存率、5年无远处转移生存率、5年疾病特异生存率分别为68.0%、67.3%、72.1%。多因素分析显示:N分期和双侧颈部淋巴结转移是影响无远处转移生存的独立预后因素。结论采用调强放疗技术治疗局部晚期鼻咽癌可提高远期疗效,远处转移是治疗失败的主要因素,N分期和双侧颈部淋巴结转移是生存率的影响因素。Objective To evaluate the 5 years results in nasopharyngeal carcinoma（NPC）patients treated by intensity modulated radiotherapy （IMRT）.Methods From January,2008 to December,2008,a total of 5 6 cases in-patients on primary NPC with stages III and IVa were treated with radical radiotherapy at our cancer center.All of which had no evidence of distant metastasis before and during the treatment.In-tensity-modulated radiotherapy with simultaneous integrated boost was used to observe the long-term effects and its influencing factors.Results The follow up rate was 94.6%,The 5-year overall survival rate,distant metastasis-free survival rate,disease specific survival rate were 68.0%,67.3% and 72.1%. Multivariate analysis showed that N stage and Bilateral cervical lymph node metastasis were the independ-ent prognostic factors for the distant metastasis-free survival.Conclusion NPC treated with IMRT could get good long-term survival.Distant metastasis was the main cause of treatment failure.N stage and Bilat-eral cervical lymph node metastasis were prognostic factors for the distant metastasis-free survival.

关 键 词：鼻咽肿瘤/放射疗法 放射疗法 调强 生存 预后 

分 类 号：R739.63[医药卫生—肿瘤]