新疆乳腺癌患者血清中Mn、Cu、Se、Zn的病例对照研究  

A contrastive study of the content change of Mn,Cu,Se,Zn in breast cancer patients′blood serum in Xinjiang

作　　者：李莉[1] 鲁英[1] 杨晓燕[1] 欧江华[2] 齐新[2] 

机构地区：[1]新疆医科大学公共卫生学院劳动卫生与环境卫生学教研室,乌鲁木齐830011 [2]新疆医科大学附属肿瘤医院乳腺外科,乌鲁木齐830011

出　　处：《新疆医科大学学报》2015年第1期67-69,共3页Journal of Xinjiang Medical University

基　　金：国家自然科学基金(81160137);新疆维吾尔自治区教育厅青年教师科研培育基金(XJEDU2011S23)

摘　　要：目的研究新疆乳腺癌患者血清微量元素锰(Mn)、铜(Cu)、锌(Zn)、硒(Se)的含量变化及其对乳腺癌的意义。方法选择2011年5月-2012年7月入住新疆医科大学附属肿瘤医院的新疆常住各族女性已确诊的原发性乳腺癌患者155例(病例组)及体检健康者155例(对照组),按照1∶1配比的病例对照研究,采用原子吸收分光光度法测定乳腺癌患者和对照组血清中微量元素Mn、Cu、Zn、Se的含量。结果经单因素分析,病例组和对照组Mn、Zn含量和Cu/Zn含量差异有统计学意义(P<0.05)。在不同临床病理分级中血清Cu、Cu/Zn差异有统计学意义(P<0.05),在不同年龄分组中血清Se差异有统计学意义(P<0.05)。PR阴性组PR阳性组血清Mn、Cu、Zn及Cu/Zn差异有统计学意义。Cu/Zn在ER阴性组和阳性组中差异有统计学意义。结论对微量元素的检测可能有助于乳腺癌的早期预防和预后。Objective The aim of this study was to investigate the trace elements （Mn,Cu,Se,Zn） content changes and the implication of these changes for breast cancer.Methods We collected 1 5 5 cases of primary breast cancer and 155 cases of healthy people from.The Affiliated Tumor Hospital of Xinjiang Medical University Between May 2011 and July 2012.1∶1 case-control method was adopted and the con-tent of trace elements in serum was determined by atomic absorption spectrophotometry.Results Univari-ate analysis showed that the difference of the content of Mn,Zn and Cu/Zn in people from two groups had statistic significance （P 〈0.05）.The difference of the content of Cu and Cu/Zn in serum was statistically significant according to the histological grading （P 〈0.05）;The difference of the content of Se in serum was statistically significant in terms of age （P 〈0.05）.Conclusion Detection of trace elements may con-tribute to early detection and help prognosis in breast cancer.

关 键 词：乳腺癌 微量元素 病例对照 

分 类 号：R737.9[医药卫生—肿瘤]