抗多药耐药靶点及相关药物的研究进展  

Research Progress in Therapeutic Targets for Multidrug Resistance and Related Drugs

作　　者：吴晨[1] 徐竹轩 周启蒙[1] 支运宝 林克江[1] 

机构地区：[1]中国药科大学药学院,江苏南京210009

出　　处：《药学进展》2014年第11期829-840,共12页Progress in Pharmaceutical Sciences

摘　　要：抗多药耐药是指在疾病的治疗过程中,细胞对多种药物产生广泛的耐受,导致治疗效果不理想的现象。多药耐药多发于感染与肿瘤疾病的治疗中,已成为治愈这2类疾病的主要障碍。从转运蛋白和离子通道、酶以及核糖体这3个方面综述抗多药耐药靶点的机制及相关药物的研究进展,旨在为抗多药耐药药物的研发提供参考。Multidrug resistance （MDR） refers to the process in which cells produce wide resistance to a variety of drugs, leading to unsatisfied treatment. Multidrug resistance mainly occurs in treatment of infections and cancers, which greatly restricts the therapeutic effects on both diseases. The research progress of anti-MDR mechanisms and drugs based on the receptor types, including transport proteins, ion channels, enzymes and ribosomes, has been reviewed in this paper, so as to provide references for the development of anti-MDR drugs.

关 键 词：多药耐药 感染 肿瘤 转运蛋白 酶 核糖体蛋白 

分 类 号：R966[医药卫生—药理学]