化痰解毒方对结直肠癌瘤体抑制作用的研究  

Study on Inhibition Effect of Huatan jiedu Prescription on Colorectal Cancer Tumor

作　　者：张欢[1] 高亭[1] 代引海[1] 

机构地区：[1]陕西中医学院第二附属医院

出　　处：《山西中医》2014年第12期34-35,共2页Shanxi Journal of Traditional Chinese Medicine

摘　　要：目的:从分子水平探讨化痰解毒方对结肠癌瘤体血管生成的抑制作用。方法 :采用免疫人VEGF单克隆抗体,通过免疫组化技术对30例结直肠癌手术切除的癌组织经过培养及给予中药化痰解毒方进行体外干预后VEGF的表达进行检测。结果:经过化痰解毒方干预的结直肠癌组织VEGF表达阳性率为16.7%(5/30),对照组为86.7%(26/30),两组比较有显著性差异(χ2=61.312,P<0.01)。结论:化痰解毒方能明显抑制VEGF在结直肠癌瘤体组织中的表达,从而阻断肿瘤新生血管的生长,揭示化痰解毒方有抑制结直肠癌的作用,从中医方面证实痰瘀、毒邪是结直肠癌发病的重要病理因素。To approach the inhibition effect of Huatanjiedu prescription on the angiogenesis of color- ectal cancer cumor from molecular level Method ： To detect the expression of VEGF, after 30 cases of cancer tissue resected due to colorectal cancer were intervened in vitro through training and giving Chinese medicine Huatan- jiedu prescription by immune human＇s VEGF monoclonal antibodies and via immunohistochemical technique. Result： After the intervention of Huatanjiedu prescription , the positive rate of VEGF expression in colorectal cancer tissue was 16. 7% （5/30）, the control group was 86.7% （26/30） ,X2 = 61. 312, P 〈0. Ol ）. Conclusion： Huatanjiedu prescription can significantly inhibit VEGF expression in the tissue of colorectal cancer tumors, thereby block the growth of tumor angiogenesis; to reveal that Huatanjiedu prescription has inhibitory effect on colorectal cancer, confirmed from traditional Chinese medicine that sputum silt and toxin factors are the important pathological factors of colorectal cancer.

关 键 词：结直肠癌 血管内皮生长因子 化痰解毒方 

分 类 号：R735.37[医药卫生—肿瘤]