Her-2表达在食管胃结合部腺癌中的作用研究进展  

Progress of Her-2 Expression in Gastroesophageal Junction Adenocarcinomas

作　　者：池苗苗 戴飞飞[1] 王亚坤[1] 谢长生[2] 

机构地区：[1]浙江中医药大学,浙江杭州310053 [2]浙江省中医院,浙江杭州310006

出　　处：《中国肿瘤》2015年第1期49-52,共4页China Cancer

基　　金：浙江省自然科学基金(LY13H290013);浙江省中医药科技计划项目(2013ZA043)

摘　　要：近几十年来,食管胃结合部腺癌的发病率正在逐年上升。Her-2表达与食管胃结合部腺癌预后的研究结果呈现争议,研究认为这是因为Her-2检测的局限性和组织标本的异质性而导致不同的结果。对于Her-2过表达的食管胃结合部腺癌,综合治疗包括新辅助放化疗、辅助放化疗、手术治疗及靶向治疗在临床疗效中的地位越来越突出,中医药治疗也在辅助治疗中起到重要作用。In recent decades, the incidence of gastroesophageal jmwtion （ GEJ ）adenocarcinomas is incl^asing. The relationship between Her-2 expression and prognosis of GEJ adenocareinomas shows controvemy. It leads to different results because of Her-2 detection limitations and tissue heterogeneity. For GEJ adenocarcinomas with Her-2 overexpression,comprehensive therapy in- cluding neoadjuvant chemotherapy,adjuvan! radiotherapy,surgery and targeted therapy is becom- ing more and more prominent in the clinic. Traditional Chinese medicine has played an important role in the adjuvant therapy.

关 键 词：食管胃结合部腺癌 人类表皮生长因子受体2 综合治疗 

分 类 号：R735[医药卫生—肿瘤]