TGF-β1基因多态性与环境交互作用对高血压的影响  

TGF-β1 Gene Polymorphisms and Environment Interaction Effect on Hypertension

作　　者：郑娟[1] 彭吉霞[2] 李贤玉[2] 熊顺华[2] 袁美春[2] 赵丹[2] 

机构地区：[1]湖北医药学院附属东风总医院儿童医疗中心,湖北十堰442000 [2]湖北医药学院,湖北十堰442000

出　　处：《辽宁中医药大学学报》2015年第1期143-145,共3页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：湖北省教育厅科学技术研究项目(Q20132103)

摘　　要：目的:研究转化生长因子β1(TGF-β1)第一外显子区+869T/C、+915G/C基因多态性及与环境易感因素的交互作用对高血压的影响。方法:采用病例对照研究的方法,用PCR-RFLP和基因测序进行基因分型。结果:+869 C等位基因及CC基因型频率在EH组中高于对照组(61.1%vs 51.2%、41.34%vs 28.57%,P<0.05),C等位基因携带者EH患病风险是T等位基因携带者的1.497倍(P=0.00);+869CC基因型与吸烟(OR=2.17,P=0.00)、饮酒(OR=2.28,P=0.01)、超重(OR=4.57,P=0.00)、肥胖(OR=26.14,P=0.00)、蔬菜摄入不足(OR=2.09,P=0.00)有正交互作用;+915G/C等位基因G、C频率依次为99.7%、0.3%(P>0.05)。结论:+869位点CC基因与蔬菜摄入不足、吸烟、饮酒、超重、肥胖共同增加了EH患病风险。Objective ： To investigate the association of the TGF-β1 gene polymorphisms and the interaction with environmental predisposing factors with essential hypertension. Methods ： Based on the casecontrol study, we used PCR-RFLP assays and gene sequencing to detect the polymorphisms of TGF-β 1. Results ： The ＋869 allele C or CC genotype in EH patients had significantly higher frequencies than controls （ 61.1% vs 51.2% ,41.34% vs 28.57%, P〈O.05 ）. TGF-β1 ＋869 C-allele carriers had significantly increased risk of EH compared with T-allele carriers （ OR=1.497, P=0.00 ）. It also showed that ＋869 CC genotype interact with smoking （ OR=2.17 ,P=0.00 ）, drinking （ OR=2.28 ,P=0.01 ）, overweight （ OR=4.57, P=0.00 ）, obesity （OR=26.14, P=0.00 ）and vegetables intaking deficiency （OR=2.09, P=0.00 ）. The frequencies of alleles G, C of ＋915G/C was 99.7%,0.3%, respectively. Conclusions： ＋ 869 CC genetype with vegetables intaking deficiency, smoking, drinking, overweight and obesity increase the risk of EH.

关 键 词：转化生长因子Β1 基因多态性 交互作用 高血压 

分 类 号：R544-1[医药卫生—心血管疾病]