银杏达莫对急性脑梗死患者血清补体C3、IL-6和IL-8的影响  

Effects of ginkgo-dipyidamolum injection on serum complement C3,IL-6 and IL-8 in acute cerebral infarction

作　　者：余高冰[1] 钟旭[1] 陈锦香[1] 

机构地区：[1]深圳市宝安区西乡人民医院,广东518102

出　　处：《社区医学杂志》2014年第24期5-7,共3页Journal Of Community Medicine

基　　金：深圳市宝安区科技局立项课题;编号:2012085

摘　　要：目的探讨银杏达莫对急性脑梗死(ACI)患者血清补体C3、白细胞介素-6(IL-6)及白细胞介素-8(IL-8)水平变化的影响。方法将ACI患者136例随机分为常规治疗对照组68例和银杏达莫治疗+常规治疗治疗组68例,分别治疗前及治疗4周后测定血清补体C3、IL-6及IL-8。同期另选40例健康体检者作参考组。结果ACI患者治疗前血清补体C3、IL-6及IL-8水平均明显高于参考组(P<0.05)。治疗组经过治疗后血清补体C3、IL-6及IL-8水平均明显低于治疗前,并且更低于对照组,差异具有统计学意义(P<0.05);与参考组比较无显著性差异(P>0.05)。对照组患者治疗前后血清补体C3、IL-6及IL-8无显著性差异(P>0.05)。结论 ACI患者应用银杏达莫治疗使补体C3、IL-6及IL-8显著降低,具有明显抗炎作用效果。Objective To explore the effects of ginkgo - dipyidamolum injection on serum complement C3, IL - 6 and IL - 8 in acute cerebral infarction（ACI）. Methods 136 cases of ACI were randomly divided into two groups： control group and routine treatment plus ginkgodipyidamolum treatment group. Both groups were detected for serum complement C3, IL - 6 and IL - 8before treatment and 4 weeks after treatment. Meanwhile, 40 healthy subjects were as the reference group. Results Before treatment, serum levels of complement C3, IL - 6 and IL - 8 were significantly higher in patients with ACI than in reference group （ P 〈 0.05 ）, but after treatment, the levels of the treatment group were obviously lower than before and even more, lower than the controls, the difference was statistically significant（ P 〈0.05 ） ; no significant - difference was found when compared to those of reference group （ P 〉 0.05 ）. Control groups showed no significant difference before and after treatment in the levels of serum complement C3, IL - 6 and IL - 8Conclusions Ginkgo - dipyi- damolum injection for ACT can lower the levels of the serum C3, IL - 6 and IL - 8, showing potent anti -inflammatory efficacy.

关 键 词：银杏达莫 白细胞介素-6 白细胞介素-8 补体C3 

分 类 号：R743.3[医药卫生—神经病学与精神病学]