稽留流产胚胎绒毛染色体异常的分析研究  

Analysis of embryo villi chromosomal abnormality in missed abortion

作　　者：任静[1] 张立军[1] 

机构地区：[1]天津医科大学第二医院产科,天津300211

出　　处：《中国妇幼健康研究》2014年第6期1057-1059,共3页Chinese Journal of Woman and Child Health Research

摘　　要：目的 探讨稽留流产与胚胎染色体异常之间的关系。方法 在无菌条件下，采集87例首次稽留流产患者的胚胎绒毛，采用长期培养法制备绒毛染色体标本，进行绒毛320～400条带染色体分析。结果 有84例绒毛染色体制备成功，绒毛培养的成功率为96．6％，其中发现核型异常45例（核型异常发生率为53．6％），染色体数目异常43例（染色体数目异常发生率为95．6％）。年龄≥35岁的患者核型异常的发生率为71．4％，＜35岁的患者核型异常的发生率为44．6％，两者比较有显著性差异（χ^2=5．385，P＜0．05）。结论 染色体数目异常是稽留流产的重要原因之一，尤其是≥35岁患者的染色体数目异常的发生率明显升高。绒毛染色体分析是稽留流产病因诊断的重要手段，可为再次生育提供优生指导依据。Objective To explore the relationship between missed abortion and embryo chromosomal abnormality .Methods Under aseptic conditions , embryo villi of 87 cases of missed abortion for the first time were collected , and long-term culture of villi chromosome specimens was prepared for 320-400 banding chromosome analysis .Results Totally 84 cases of villi chromosome were successfully prepared , with the successful rate of 96.6%.There were 45 cases with abnormal karyotype （ incidence of 53.6%） and 43 cases with abnormal chromosome number （incidence of 95.6%）.The incidence of abnormal karyotype in patients older than and equal to 35 was 71.4%, and that in patients younger than 35 was 44.6%.The difference was significant （χ^2=5.385,P〈0.05）.Conclusion Abnormal chromosome number is one of the important causes of missed abortion .The incidence of chromosome number abnormality is especially high in patients older than and equal to 35.Villi chromosome analysis is an important means of diagnosing missed abortion pathogeny , and it can provide basis for guidance of eugenics in birth again .

关 键 词：稽留流产 染色体异常 核型分析 优生优育 

分 类 号：R714[医药卫生—妇产科学]