TAp63基因在多发性骨髓瘤中的表达及作用  

Expression and significance of TAp63 gene in multiple myeloma

作　　者：刘善浩[1] 

机构地区：[1]皖南医学院附属弋矶山医院血液内科,安徽芜湖241001

出　　处：《皖南医学院学报》2014年第6期483-485,共3页Journal of Wannan Medical College

基　　金：院中青年科研基金项目(WK2012F13)

摘　　要：目的:探讨TAp63 mRNA在多发性骨髓瘤(MM)中的表达及其在MM发病和预后中的可能作用。方法:采用RTPCR检测19例MM患者骨髓及10例非恶性血液病患者骨髓中TAp63 mRNA的表达水平。结果:TAp63 mRNA在MM患者骨髓及非恶性血液病患者骨髓中平均灰度值分别为0.912±0.424、0.315±0.035,两者比较有显著性差异(P<0.001);其中ISS分期Ⅲ期患者的TAp63 mRNA平均灰度值显著高于Ⅰ期及Ⅱ期患者(P=0.000),同时MM患者TAp63 mRNA的表达强度与血清β2MG有显著正相关性(r=0.607,P=0.006)。结论:TAp63基因在MM患者中呈现了高表达状态,参与了MM的发生、发展,并与预后相关。Objective：To investigate the expression of TAp63 mRNA in multiple myeloma （ MM） and its potential role in pathogenesis and prognosis. Methods：Reverse transcription polymerase chain reaction（RT-PCR） was used to determine the marrow level of TAp63 mRNA in 19 patients with MM and another 10 of hematologic non-malignancies.Results：TAp63 mRNA expression level was 0.912 ±0.424 for the MM patients and 0.315 ±0.035 for the hematologic non-malignancies.The two groups were significantly different（P〈0.001）.By the International Staging System（ISS） for multiple myeloma, the mean level of TAp63 mRNA in patients at stage Ⅲ was significantly higher than those at stage Ⅰ and Ⅱ（P=0.000）,and the TAp63 mRNA expres-sion was positively related to serum β2MG in MM patients（r=0.607;P=0.607）.Conclusion：TAp63 presents a higher expression in patients with MM, suggesting that this gene is involved in the occurrence and development of MM ,and may be an indicator to estimate the prognosis .

关 键 词：多发性骨髓瘤 TAP63 Β2MG 

分 类 号：R733.3[医药卫生—肿瘤]