Epstein-Barr virus and nasopharyngeal carcinoma  

作　　者：Lawrence S.Young Christopher W.Dawson 

机构地区：[1]Warwick Medical School, The University of Warwick [2]School of Cancer Sciences, University of Birmingham

出　　处：《Chinese Journal of Cancer》2014年第12期581-590,共10页

基　　金：supported by Cancer Research UK and the European Commission’s FP6 Life-Sciences-Health Programme(INCA Project:LSHC-CT-2005-018704)

摘　　要：Since its discovery 50 years ago,Epstein-Barr virus(EBV)has been linked to the development of cancers originating from both lymphoid and epithelial cells.Approximately 95%of the world’s population sustains an asymptomatic,life-long infection with EBV.The virus persists in the memory B-cell pool of normal healthy individuals,and any disruption of this interaction results in virus-associated B-cell tumors.The association of EBV with epithelial cell tumors,specifically nasopharyngeal carcinoma(NPC)and EBVpositive gastric carcinoma(EBV-GC),is less clear and is currently thought to be caused by the aberrant establishment of virus latency in epithelial cells that display premalignant genetic changes.Although the precise role of EBV in the carcinogenic process is currently poorly understood,the presence of the virus in all tumor cells provides opportunities for developing novel therapeutic and diagnostic approaches.The study of EBV and its role in carcinomas continues to provide insight into the carcinogenic process that is relevant to a broader understanding of tumor pathogenesis and to the development of targeted cancer therapies.Since its discovery 50 years ago, Epstein-Barr virus （EBV） has been linked to the development of cancers originating from both lymphoid and epithelial cells. Approximately 95% of the world＇s population sustains an asymptomatic, life-long infection with EBV. The virus persists in the memory B-cell pool of normal healthy individuals, and any disruption of this interaction results in virus-associated B-cell tumors. The association of EBV with epithelial cell tumors, specifically nasopharyngeal carcinoma （NPC） and EBV- positive gastric carcinoma （EBV-GC）, is less clear and is currently thought to be caused by the aberrant establishment of virus latency in epithelial cells that display premalignant genetic changes. Although the precise role of EBV in the carcinogenic process is currently poorly understood, the presence of the virus in all tumor cells provides opportunities for developing novel therapeutic and diagnostic approaches. The study of EBV and its role in carcinomas continues to provide insight into the carcinogenic process that is relevant to a broader understanding of tumor pathogenesis and to the development of targeted cancer therapies.

关 键 词：EPSTEIN-BARR病毒 鼻咽癌 肿瘤细胞 上皮细胞 EB病毒 癌症治疗 细胞起源 世界人口 

分 类 号：R739.63[医药卫生—肿瘤]