Epstein-Barr virus and the origin of Hodgkin lymphoma  

作　　者：Martina Vockerodt Fathima Zumla Cader Claire Shannon-Lowe Paul Murray 

机构地区：[1]School of Cancer Sciences, University of Birmingham

出　　处：《Chinese Journal of Cancer》2014年第12期591-597,共7页

摘　　要：Although Epstein-Barr virus(EBV)is present in the malignant Hodgkin/Reed-Sternberg(HRS)cells of a proportion of cases of classical Hodgkin lymphoma(c HL),how the virus contributes to the pathogenesis of this disease remains poorly defined.It is clear from the studies of other EBV-associated cancers that the virus is usually not sufficient for tumor development and that other oncogenic co-factors are required.This article reviews what is known about the contribution of EBV to the pathogenesis of c HL and focuses on emerging evidence implicating chronic inflammation as a potential oncogenic co-factor in this malignancy.Although Epstein-Barr virus （EBV） is present in the malignant Hodgkin/Reed-Sternberg （HRS） cells of a proportion of cases of classical Hodgkin lymphoma （cHL）, how the virus contributes to the pathogenesis of this disease remains poorly defined. It is clear from the studies of other EBV-associated cancers that the virus is usually not sufficient for tumor development and that other oncogenic co-factors are required. This article reviews what is known about the contribution of EBV to the pathogenesis of cHL and focuses on emerging evidence implicating chronic inflammation as a potential oncogenic co-factor in this malignancy.

关 键 词：EPSTEIN-BARR病毒 淋巴瘤 起源 金 恶性肿瘤 发病机制 辅助因子 EBV 

分 类 号：R733.1[医药卫生—肿瘤]