伐昔洛韦联合阿莫西林和甲硝唑作为辅助疗法治疗重度慢性牙周炎的疗效观察  

Valacyclovir,Amoxicillin and Metronidazole as an Adjunctive Treatment in Advanced Periodontitis

作　　者：付永伟[1] 李向新[1] 杨雁[1] 龚永庆[1] 徐宏志[1] 

机构地区：[1]连云港市第一人民医院口腔科,江苏连云港222002

出　　处：《口腔医学研究》2014年第12期1194-1197,1200,共5页Journal of Oral Science Research

摘　　要：目的:评价伐昔洛韦联合阿莫西林和甲硝唑作为辅助疗法治疗重度慢性牙周炎的临床疗效。方法:将61例重度慢性牙周炎患者随机分为对照治疗组(n=30)和干预治疗组(n=31)。对所有患者进行口腔卫生指导、龈上洁治和抛光。龈上洁治后1周内,干预治疗组予伐昔洛韦口服,对照治疗组予安慰剂口服。在基线点以及牙周治疗后2和6个月时对所有患者进行牙周检查。采用SPSS17.0软件包对数据进行统计学分析。结果:在基线时,对照治疗组与干预治疗组间牙周指标的差异均无统计学意义。治疗后2个月和6个月,干预治疗组探诊出血(bleeding on probing,BOP)阳性位点百分比减少值、牙周探诊深度(probing depth,PD)≥4 mm的位点百分比减少值和PD的减少值均显著高于对照治疗组,差异有统计学意义(P<0.05),干预治疗组临床附着水平(clinical attachment level,CAL)的减少值与对照治疗组比较虽有所升高,但差异无统计学意义。结论:在重度慢性牙周炎的牙周机械治疗过程中,与应用阿莫西林和甲硝唑作为辅助治疗相比,联合应用伐昔洛韦、阿莫西林和甲硝唑作为辅助治疗可进一步提高临床疗效。Objective：To evaluate the clinical benefit of valacyclovir,amoxicillin and metronidazole when performing full-mouth periodontal debridement in patients with advanced chronic periodontitis.Methods：61patients with advanced chronic periodontitis were randomly assigned into control-treatment group（n=30）and intensive-treatment group（n=31）.All patients were given instructions in basic oral hygiene and underwent a standard cycle of supragingival mechanical scaling and polishing.Periodontal parameters were evaluated before treatment and 2and 6months after treatment.The statistical analysis was performed using SPSS17.0software package.Results：No differences in clinical parameters were noted before treatment.Two and six months after treatment,the mean percentage reduction of sites with BOP and PD≥4mm were significantly higher in the intensive-treatment group than in the control-treatment group（P〈0.05）.Similarly,patients in the intensive-treatment group had higher mean PD reduction than those in the control-treatment group 2 months after therapy（P〈0.05）and 6 months after therapy（P〈0.05）.However,the mean values of CAL reduction were slightly,but not significantly,higher in the intensive-treatment group than in the control-treatment group 2months after therapy and 6months after therapy.Conclusion：At 6months,patients who received valacyclovir,amoxicillin and metronidazole showed statistically significant benefits compared with those who only received amoxicillin and metronidazole.

关 键 词：牙周炎 伐昔洛韦 阿莫西林 甲硝唑 随机对照试验 

分 类 号：R781.4[医药卫生—口腔医学]