胃癌组织中TSLC1的表达及临床意义  

Expression of TSLC1 in human gastric cancer and its clinical significance

作　　者：阳帅[1] 胡华[2] 王晓瑜[2] 赵强[1] 张小丽[1] 

机构地区：[1]南华大学附属第一医院病理科,衡阳421001 [2]南华大学附属第二医院病理科,衡阳421001

出　　处：《临床与实验病理学杂志》2014年第12期1339-1341,共3页Chinese Journal of Clinical and Experimental Pathology

基　　金：国家自然科学青年基金(81401960)

摘　　要：目的探讨肺癌肿瘤抑制物1(tumor suppressor in lung cancer 1,TSLC1)蛋白表达与胃癌发生、发展的关系。方法采用免疫组化法检测TSLC1蛋白在20例正常胃黏膜、30例胃上皮内瘤变和50例胃癌组织中的表达,并复习相关文献。结果TSLC1在胃癌中的阳性率为14.00%,低于胃上皮内瘤变(46.67%)及正常胃黏膜(95.00%)(P<0.05)。TSLC1在高级别上皮内瘤变中的表达低于低级别上皮内瘤变及正常胃黏膜(P<0.05)。TSLC1在高级别上皮内瘤变及胃癌组织中的表达差异无显著性(P>0.05)。胃癌中TSLC1表达与淋巴结转移和TNM分期密切相关(P<0.05)。结论 TSLC1表达与胃癌的发生、发展有关,可能为胃癌的防治提供新方向。Purpose To explore the relationship between tumor suppressor in lung cancer 1 （TSLC1） protein expression and the carci-nogenesis and progression of human gastric carcinoma. Methods Expression of TSLC1 protein in 20 normal gastric mucosa, 30 intra-epithelial neoplasias （ IN） and 50 gastric cancers was examined by immunohistochemistry. Results The expression of TSLC1 in gas-tric cancer was 14. 00% which was lower than that in IN （46. 67%） and normal gastric mucosa （95. 00%, P〈0. 05）. TSLC1 ex-pression in high-grade IN was lower than that in low-grade IN and normal gastric mucosa （P〈0. 05）. TSLC1 expression in high-grade IN and gastric cancer was of no significant difference （ P〉0. 05 ） . Expression of TSLC1 was significantly associated with lymph node metastasis and TNM in gastric cancer （P〈0. 05）. Conclusion The expression of TSLC1 is closely related to carcinogenesis, lymph node metastasis and clinical stage in gastric cancer, which suggest that TSLC1 may be a new target for the prevention and treatment of gastric cancer.

关 键 词：胃肿瘤 TSLC1 免疫组织化学 

分 类 号：R735.2[医药卫生—肿瘤]