中晚期非小细胞肺癌调强放疗临床疗效  

Clinical effect of intensity modulated radiation therapy for treatment of local medium and advanced non-small cell lung cancer

作　　者：陈云萍[1] 李建成[2] 张江灵[1] 洪朝欣 罗丹凤[1] 赖章超[1] 

机构地区：[1]解放军第180医院肿瘤科,福建泉州362000 [2]福建省肿瘤医院放疗科,福建福州350000

出　　处：《临床荟萃》2015年第1期48-51,共4页Clinical Focus

摘　　要：目的：分析中晚期非小细胞肺癌调强放疗的近期疗效及不良反应。方法159例经病理组织学和（或）细胞学确诊的中晚期非小细胞肺癌患者接受调强放疗，肺部病灶分割剂量200～220 cGy／次、5次／周，肺部病灶放疗总量6000～6600 cGy。结果总有效率为76．7％。1，2，3年局部控制率分别为49．5％、28．8％、13．4％，中位无进展时间11．9个月；1，2，3年生存率分别为70．0％、44．5％、25．6％，中位生存期19．9个月；1，2，3年无远处转移生存率分别为57．9％、39．6％、27．5％。放射性肺炎、放射性食管炎及骨髓抑制发生率分别为20．1％（32／159）、19．5％（31／159）、39．6％（63／159）。结论中晚期非小细胞肺癌调强放疗的临床疗效好，不良反应可以耐受，长期疗效有待临床进一步研究。ABSTRACT：Objective To evaluate the clinical toxicity and value of intensity modulated radiation therapy for the treatment of local medium and advanced non-small cell lung cancer.Methods The study included 159 patients with local medium and advanced non-small cell lung cancer diagnosed by pathology and/or cytology who received intensity modulated radiation therapy.Lung tumor received total dose from 6 000 to 6 600 cGy at 200-220 cGy/fraction,5 fractions/week.Results The overall response rate was 76.7%.The 1-2-and 3-year local control rates were 49.5%, 28.8%,13.4%,respectively.The median progression-free time was 11.9 months;the 1-,2-and 3-year overall survival rate were 70.0%,44.5%,25.6%,respectively,the median survival period was 19.9 months;the 1-,2-and 3-year none distant metastasis rates were 57.9%,39.6%,27.5%,respectively.Radioactive pneumonia,radioactive esophagitis and myelosuppression rates were 20.1% （32/159 ）,19.5% （31/159 ）,39.6% （63/159 ）,respectively.Conclusion The clinical curative effect of intensity modulated radiation therapy for the treatment of local medium and advanced non-small cell lung cancer is excellent,and the side reactions can be tolerated.Long-term efficacy remains further clinical research.

关 键 词：癌 非小细胞肺 放射疗法 预后 

分 类 号：R734.2[医药卫生—肿瘤]