多脏器功能障碍综合征患者连续性血液滤过治疗肝素用量与病情危重程度及预后的相关性  

Relationship between permissible dose of heparin and severity of illness and prognosis in patients with multiple organ dysfunction syndrome during continuous veno-venous hemofiltration

作　　者：田惠玉[1] 姜相明[1] 宋邵华[1] 张杰[1] 陆鹏[1] 金玉洁[1] 杨秀芬[1] 

机构地区：[1]河北医科大学第一医院重症医学科,河北石家庄050031

出　　处：《临床荟萃》2015年第1期67-70,共4页Clinical Focus

基　　金：河北省卫生厅医学科学研究重点课题(20100270)

摘　　要：目的探讨多脏器功能障碍综合征(multiple organ dysfunction syndrome MODS)患者连续性血液滤过治疗肝素许可用量与预后的相关性分析。方法选择我院MODS行连续性血液滤过治疗患者60例,依据预后分为死亡组和存活组。评估肝素许可用量与病情危重程度及预后的相关性。结果 1肝素的平均许可用量(8.27±1.19)U·kg-1·h-1。死亡组肝素的许可用量明显少于存活组,(6.55±1.48)U·kg-1·h-1 vs(9.59±0.96)U·kg-1·h-1(P<0.05)。2肝素的许可用量与年龄、APACHEⅡ评分呈明显负相关(r=-0.550,-0.563,P<0.01)。结论MODS患者连续性血液滤过治疗中肝素的许可用量与MODS患者的预后密切相关。ABSTRACT：Objective To investigate the relationship between permissible dose of heparin and the severity of illness and the prognosis of the patients with multiple organ dysfunction syndrome（MODS）during continuous veno-venous hemofiltration（CVVH）.Methods Sixty patients with MODS undergoing CVVH in our hospital were divided into death group and survival group according to their prognosis.The relationship between the permissible dose of heparin and the severity of illness and the prognosis of the patients were assessed.Results The mean permissible dose of heparin in the death group was significantly less than that in the survival group （6.55±1.48 U·kg^-1 ·h^-1 vs 9.59±0.96 U·kg^-1 ·h^-1 ,P 〈0.05）.Moreover,the permissible dose of heparin had significantly negative correlation with ages and APACHE Ⅱ scores of the patients （r = -0.550,-0.563,respectively;P 〈0.01 ）.Conclusion The permissible dose of heparin is closely correlated with the prognosis of the patients with MODS.

关 键 词：多器官功能衰竭 血液滤过 肝素 预后 

分 类 号：R365[医药卫生—病理学]