预防性持续低剂量咖啡因治疗超低出生体质量儿呼吸暂停疗效观察  

The curative effect observation of preventing extremely low birth weight infants apnea by persistent low doses of caffeine

作　　者：齐卫斌[1] 魏彦敏 翟娜 魏江玲 张军华 曹巧娜 

机构地区：[1]石家庄市第四医院,050011 [2]河北省无极县医院,052460

出　　处：《临床合理用药杂志》2015年第1期46-47,共2页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的观察预防性持续低剂量咖啡因在超低出生体质量儿呼吸暂停治疗中的临床疗效。方法将超低出生体质量儿208例随机分为试验组和对照组各104例。试验组患儿在出生后尚未发生呼吸暂停时给予持续低剂量咖啡因治疗,对照组患儿在发生呼吸暂停后才开始接受咖啡因治疗。比较并评价2组患儿治疗效果。结果试验组在患儿出生1周内呼吸暂停发生率和体质量增至2.0kg前呼吸暂停发生率均低于对照组,差异均有统计学意义(P<0.05)。试验组反复发生呼吸暂停而使用呼吸机的百分率低于对照组,差异有统计学意义(P<0.05)。结论持续低剂量咖啡因用于预防超低出生体质量儿呼吸暂停,能够有效缓解患儿的病症。Objective To observe the curative effect of preventing extremely low birth weight infants apnea by persis-tent low doses of caffeine. Methods 280 extremely low birth weight newborn were randomly divided into the test group and the control group,each of 104 cases. The test group were given continuous low dose caffeine treatment before the infants hadn＆#39;t oc-curred apnea. The control group were treated after birth hd apnea. Compared and evaluated the treatment effect of the two groups. Results The test group in infant within 1 weeks of apnea occurrence rate and body mass increased to 2. 0kg before ap-nea occurrence rate was lower than that of control group,the differences were statistically significant（P〈0. 05）. The using ventilator percentage of test groupwas lower than in the control group,the difference was statistically significant（P〈0. 05）. Conclusion Persistent low dose of caffeine can prevent extremely low birth weight infants apnea,and can alleviate the infants＆#39;symptoms effectively.

关 键 词：咖啡因 低剂量 持续 超低出生体质量 婴儿 呼吸暂停 

分 类 号：R722.6[医药卫生—儿科]