正常大鼠部分脑组织切除术后术区周边脑组织 MRI 增强特点及其病理学研究  

Correlation of MRI enhancement features and histopathology after partial resection of nomal brain：an experimental study in rats

作　　者：王文娟[1] 徐敏[1] 孙永红[2] 王晓莉[1] 葛艳明[1] 董鹏[1] 

机构地区：[1]潍坊医学院附属医院影像中心 [2]潍坊医学院附属医院病理科,山东潍坊261031

出　　处：《实用放射学杂志》2014年第12期2076-2078,2093,共4页Journal of Practical Radiology

基　　金：山东省自然科学基金资助项目（ZR2010 HM078）。

摘　　要：目的：研究正常大鼠部分脑组织切除后术区周边脑组织 MRI 增强特点及其病理学基础。方法42只清洁级成年 Spra-gue Dawley 大鼠随机分为术后1 d、3 d、7 d、14 d、21 d 和28 d 组及正常对照组。制作正常大鼠部分脑组织切除模型,对照组不做任何处理。行鼠脑 T1 WI、T2 WI 和增强 T1 WI 成像,观察术后不同时间点术区周边脑组织和正常对照组相应部位 MRI 增强特点。MR 检查完成后立即处死动物,观察相应时间点术区周边脑组织的病理学改变。结果（1）术后1 d 即可看到术区周边脑组织的反应性强化,且强化一直持续到第28 d；（2）术后7 d 术区周边脑组织的强化比值最高,但与术后14 d 间差异无统计学意义（P 〉0.05）,术后21 d、28 d 强化程度逐渐减弱；（3）术后7 d,术区周边脑组织的新生血管数量最多,高于其余手术各组及对照组（P 0.05）。结论正常大鼠部分脑组织切除术后,术区周边脑组织 MRI 增强特点具有明显的时间演变规律,且与新生血管形成具有相关性。Objective To study the contrast enhanced magnetic resonance imaging （MRI）features of surgical margin and its path-ologic basis of the experimental rat model by resecting partial brain tissue.Methods Forty-two rats were randomly divided into six experimental groups （postoperative 1d,3d,7d,14d,21d,28d groups）and one contrast group.A partial resection of the parietooc-cipital region was performed.MRI procedures consisted of T1 WI and T2 WI and contrast enhanced T1 WI,pre-and postcontrast scan-ning were enforced in different postoperative days.Brain tissue samples were obtained after MRI examination.Pathological study was made and the results were compared with MRI findings.Results （1 ）The earliest enhancement was observed around surgical margin on the first day after surgery,which enhancement was lasted until 28 days;（2）The enhancement of the surgical margin was significantly increased after 7d,the signal intensity ratio in this period reached the peak,but this ratio between 7d and 14d had no ob-vious disparation.The degree of enhancement gradually weakened in the next few days;（3）The number of neovessels reached the peak at 7d,which was higher than that at other experimental groups and contrast group （P 0.05）.Conclusion The contrast enhanced MRI features of the surgical margins after resected partial brain tissue is related to the time of the postoperation,and the neovascularization plays an importent role in this process.

关 键 词：大鼠 脑 术后 磁共振成像 

分 类 号：R-332[医药卫生] R322.81