Kaposi's sarcoma-associated herpesvirus:Towards better understanding of its latency and pathogenesis  

作　　者：SUN Rui LIANG DeGuang LAN Ke 

机构地区：[1]Institut Pasteur of Shanghai,Chinese Academy of Sciences

出　　处：《Science Foundation in China》2014年第2期55-67,共13页中国科学基金（英文版）

基　　金：supported by the National Science Fund for Distinguished Young Scholars(Grant No.81425017);the Key Project of National Natural Science Foundation of China(Grant No.81230037);the National Basic Research Program of China(Grant No.2011CB504800);supported by the National Natural Science Foundation of China(Grant No.81201279);CAS Youth Innovation Promotion Association

摘　　要：Kaposi's sarcoma-associated herpesvirus(KSHV) is a double stranded DNA virus.It was found to be related to Kaposi's sarcoma(KS),primary effusion lymphoma(PEL) and multicentric Castleman's disease(MCD),which cause severe illness in AIDS patients.As a member of human herpesvirus family,KSHV displays two distinct phases in its life cycle,the default latent and lytic replication phase.Following primary infection,the virus can quickly establish latent infection in the host.However,it is still not fully understood up to date how KSHV establishes and maintains viral latency in the host cells.KSHV mainly infects endothelial cells in the host,promoting proliferation and angiogenesis.Abundant angiogenesis is the key feature of KS and is the critical factor for KS progression.The mechanism of KSHV mediated pathogenesis is also largely unknown.In this review,we summarize the recent progress in the mechanisms of KSHV latency and pathogenesis,with particular views from our work.Kaposi＇s sarcoma-associated herpesvirus （KSHV） is a double stranded DNA virus. It was found to be related to Kaposi＇s sarcoma （KS）, primary effusion lymphoma （PEL） and multicentric Castleman＇s disease （MCD）, which cause severe illness in AIDS patients. As a member of human herpesvirus family, KSHV displays two distinct phases in its life cycle, the default latent and lytic replication phase. Following primary infection, the virus can quickly establish latent infection in the host. However, it is still not fully understood up to date how KSHV establishes and maintains viral latency in the host cells. KSHV mainly infects endothelial cells in the host, promoting proliferation and angiogenesis. Abundant angiogenesis is the key feature of KS and is the critical factor for KS progression. The mechanism of KSHV mediated pathogenesis is also largely unknown. In this review, we summarize the recent progress in the mecha- nisms of KSHV latency and pathogenesis, with particular views from our work.

关 键 词：KSHV LATENCY PATHOGENESIS RTA LANA Notch BMP signaling 

分 类 号：R373.11[医药卫生—病原生物学]