664例垂体后叶素致低钠血症文献分析  

Literature Analysis of 664 Cases of Hypophysin-induced Hyponatremia

作　　者：李黎明[1] 

机构地区：[1]河南省人民医院ICU,郑州450002

出　　处：《中国药房》2015年第2期231-234,共4页China Pharmacy

摘　　要：目的:提示临床重视垂体后叶素致低钠血症,为其合理应用及完善说明书提供参考。方法:以"垂体后叶素""低钠血症"等为检索词,检索中国期刊全文数据库(CNKI)截至2014年6月文献,按纳入与排除标准共纳入34篇文献、664例病例,进行资料提取,按患者性别、年龄、用药剂量、临床表现等进行统计;另对国内3个厂家的药品说明书进行对比分析。结果:垂体后叶素致低钠血症较常见,且严重低钠血症可危及生命;说明书中未见有低钠血症的风险提示。结论:临床应重视垂体后叶素致低血钠的风险,药品说明书应得以完善,确保临床用药安全。OBJECTIVE： To prompt the clinicals attach importance to the hyponatremia induced by hypophysin, and to provide reference for its rational application and the improvement of drug package inserts. METHODS： Using ＂hypophysin＂ and ＂hypona- tremia＂ as key words, retrieving CNKI up to Jun. 2014, 34 literatures were included according to inclusion and exclusion criteria. 664 medical cases were extracted and analyzed statistically in respects of patient＇s gender, age, drug dosage, clinical manifesta- tions, etc. The package inserts of drugs from 3 manufacturers were analyzed comparatively. RESULTS： Hyponatremia induced by hypophysin is very common. The life may be threatened by severe hyponatremia, and there is no warning of hyponatremia in the drug package insert. CONCLUSIONS： Great importance should be attached to the risk of hyponatremia induced by hypophysin and the improvement of drug package inserts so as to ensure the safety of drug use in the clinic.

关 键 词：垂体后叶素 低钠血症 药品说明书 分析 

分 类 号：R969.3[医药卫生—药理学] R973.1[医药卫生—药学]