盐酸度洛西汀联合盐酸乙哌立松治疗慢性紧张型头痛的临床研究  

Clinical Study of Duloxetine Hydrochloride Combined with Eperisone Hydrochloride in the Treatment of Chronic Tension-type Headache

作　　者：赵艳[1] 唐明山[1] 邹耀兵 肖静[1] 潘成德[1] 江思德[1] 

机构地区：[1]重庆市巴南区人民医院神经内科,重庆401320

出　　处：《中国药房》2015年第2期248-251,共4页China Pharmacy

摘　　要：目的:评价盐酸度洛西汀联合盐酸乙哌立松治疗慢性紧张型头痛的疗效。方法:收集神经内科门诊及住院就诊的符合慢性紧张型头痛诊断标准的患者220例,依据汉密尔顿抑郁量表(HAMD17)、汉密尔顿焦虑量表(HAMA14)评价患者的情感障碍状态,将其分为A组(不伴焦虑抑郁组,124例)和B组(伴焦虑抑郁组,96例),A、B组再各自随机分为治疗组(A1组62例,B1组48例)和对照组(A2组62例,B2组48例);对照组单用盐酸乙哌立松治疗,治疗组在此基础上加用盐酸度洛西汀。分别于治疗前与治疗2周末、4周末、8周末统计患者头痛发作次数、持续时间、头痛程度;B组(伴焦虑抑郁)患者同时采用HAMD17、HAMA14评价患者的抑郁、焦虑程度。结果:治疗后,A、B两组中治疗组患者的头痛发作次数、头痛持续时间、头痛程度与对照组比较,差异有统计学意义(P<0.05);治疗2周末、4周末、8周末,B组(伴焦虑抑郁)患者的HAMD、HAMA评分与对照组比较,差异有统计学意义(P<0.01);治疗后A、B两组患者中,治疗组的总有效率与对照组比较,差异有统计学意义(P<0.05);两组患者均未见明显不良反应发生。结论:盐酸度洛西汀联合乙哌立松治疗伴或不伴焦虑、抑郁的慢性紧张型头痛患者的疗效较好、安全性高。OBJECTIVE:To evaluate therapeutic efficacy of duloxetine hydrochloride combined with eperisone hydrochloride in the treatment of chronic tension-type headache. METHODS:220 patients with chronic tension-type headache were collected from the outpatient and inpatient department of neurology. According to affective disorder evaluation by using Hamilton Depression Scale(HAMD17)and Hamilton Anxiety Scale(HAMA14),they were divided into group A(without anxiety and depression group,124cases)and group B(with anxiety and depression group,96 cases). Group A and group B respectively were randomly divided into treatment group(group A1 of 62 cases,group B1 of 48 cases)and control group(group A2 of 62 cases,group B2 of 48 cases). Control group was given eperisone hydrochloride alone,and treatment group additionally received duloxetine hydrochloride on the basis of control group. The attack frequency,duration and degree of headache were recorded before treatment,2 weeks,4 weeks and 8 weeks after treatment. The degrees of depression and anxiety of patients in group B were evaluated by HAMD17 and HAMA14. RESULTS:After treatment,there was statistical significance in attack frequency,duration and degree of headache in group A1 and B1,compared with control group(P<0.05).There was statistical significance in scores of HAMD and HAMA in group B1(with anxiety and depression group)2 weeks,4 weeks and 8 weeks after treatment,compared with control group(P<0.01). There was statistical significance in total effective rate of group A1 and B1after treatment,compared with control group(P<0.05). No obvious ADR was found in 2 groups. CONCLUSIONS:Duloxetine hydrochloride combined with eperisone hydrochloride is effective for chronic tension-type headache with or without anxiety and depression.

关 键 词：盐酸度洛西汀 盐酸乙哌立松 慢性紧张型头痛 抑郁 焦虑 疗效 

分 类 号：R749.7[医药卫生—神经病学与精神病学] R969.4[医药卫生—临床医学]