中医药对慢性骨筋膜室综合征及肌纤维类型转化中CaN-NFAT及PPAR/PGC-1信号通路的研究进展  

Review on the effects of TCM on chronic exertional compartment syndrome, and signaling pathways of CaN-NFAT or PPAR/PGC-1 in muscle fiber type conversion

作　　者：徐崇艺 尹仁芳[2] 于战歌 王荣国[4] 

机构地区：[1]北京中医药大学针灸推拿学院,100029 [2]中国中医科学院中医药信息研究所办公室,北京100700 [3]浙江省温岭市中医院妇产科,317500 [4]北京中医药大学研究生院,100029

出　　处：《国际中医中药杂志》2015年第1期83-86,共4页International Journal of Traditional Chinese Medicine

基　　金：2013年北京高等学校“青年英才计划”（YETP0795）

摘　　要：抗疲劳能力下降是慢性骨筋膜室综合征患者最重要的临床症状之一。骨筋膜室内压增高后Ⅰ型、Ⅱ型骨骼肌肌纤维比例改变是导致肌纤维抗疲劳能力下降的重要原因。CaN-NFAT 和PPAR/PGC-1信号通路与肌纤维类型转化有密切关系。研究证实中医药可通过激活 CaN-NFAT 信号通路或抑制PPAR/PGC-1信号通路保护机体组织。因此，为更好的分析上述研究特作此综述。The anti-fatigue ability decline is one of the most important clinical symptoms of chronic exertional compartment syndrome （CECS）. The percentage change of type-I and II skeletal-muscle fiber is an important reason for anti-fatigue ability decline after intracompartmental pressure increase. There is a close relationship between CaN-NFAT or PPAR/PGC-1 signaling pathways and muscle fiber type conversion. Studies have confirmed that Traditional Chinese medicine can protect the body tissue by activing CaN-NFAT or inhibiting PPAR/PGC-1 signaling pathways. Therefore, we wrote the review in order to better analyze the research progress in this field.

关 键 词：慢性骨筋膜室综合征 肌纤维类型 钙调神经磷酸酶 过氧化物酶体增殖物激活受体 过氧化物酶体增殖物激活受体γ辅激活因子-1 

分 类 号：R274.9[医药卫生—中西医结合]