大肠癌中STAT3、Twist的表达及与EMT关系的研究  

Study on the Expression of STAT3, Twist in Colorectal Carcinoma and Its Relationship with EMT

作　　者：钟宝元[1] 

机构地区：[1]赣南医学院第一附属医院,江西赣州341000

出　　处：《中国医学创新》2014年第36期33-34,共2页Medical Innovation of China

基　　金：赣南医学院基础研究项目(ZD201304)

摘　　要：目的:分析与探讨大肠癌中STAT3、Twist的表达及与EMT(上皮细胞间质化)的关系。方法:选取本院结直肠癌、癌旁组织标本各80例,采用免疫组化方法检测STAT3、Twist及EMT相关蛋白的表达。结果:大肠癌中Twist与STAT3蛋白阳性率明显高于癌旁组织(P<0.05);大肠癌中EMT阳性率明显低于癌旁组织(P<0.05);STAT3、Twist的表达和EMT呈现正相关性(P<0.05)。结论:大肠癌中SATA3与Twist表达和肿瘤生物学特征存在相关性,临床检测STAT3、Twist及EMT有助于预测肿瘤侵袭转移与判断预后。Objective：To investigate the expression of STAT3 in colorectal cancer, Twist and EMT（epithelial mesenchymal） relationship.Method：80 cases of adjacent tissues of colorectal cancer, cancer specimens were selected in our hospital, the expression of STAT3 and Twist and EMT related proteins were detected used immunohistochemical method.Result：Twist and STAT3 protein in colorectal cancer were significantly higher than the tissue adjacent to carcinoma（P〈0.05）. EMT in colorectal cancer were obviously lower than the tissue adjacent to carcinoma（P〈0.05）. The expression of STAT3 and Twist and EMT present positive correlation（P〈0.05）. Conclusion：SATA3 and Twist expression in colorectal cancer and no correlation between tumor biological characteristics, clinical detection of STAT3, Twist and EMT help predict tumor invasion and metastasis and prognosis.

关 键 词：大肠癌 STAT3 TWIST EMT 

分 类 号：R735.34[医药卫生—肿瘤]