阿司匹林对高糖诱导的脑梗死出血转化大鼠模型的影响  

Effection of aspirin on acute hyperglycemia-enhanced hemorrhagic transformation in a rat model of cerebral ischemia

作　　者：李薇[1] 陈吉相[1] 苏颖[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院神经内科,湖北武汉430022

出　　处：《中风与神经疾病杂志》2014年第12期1078-1080,共3页Journal of Apoplexy and Nervous Diseases

摘　　要：目的探讨脑梗死早期出血转化使用阿司匹林是否可加重血脑屏障的损害。方法用高糖诱导大鼠脑缺血再灌注出血转化模型。大鼠随机分为3组,于缺血再灌注术后12 h、24 h、48 h、72 h分别给予2 ml蒸馏水、阿司匹林2 mg、阿司匹林6 mg灌胃,常规饲料饲养72 h,并进行神经功能评分、测量大鼠体重。再灌注72 h后取脑测量脑组织出血量、MMP量及EB渗出量。结果 (1)3组大鼠间缺血脑组织出血量、EB渗出量、MMP-2量、体重差值无明显差异;(2)2 mg阿司匹林组72 h神经功能评分与术后12 h神经功能评分差值与对照组相比较大(P<0.05)。结论高糖诱导的HT后12 h开始使用阿司匹林并不能加重血脑屏障破坏,对神经功能的恢复是有利的。Objective To explore whether using aspirin can increase the blood brain barrier damage in the early stage of hyperglycemia-enhanced hemorrhage transformation in a rat model of cerebral infarction. Methods Rats were randomly divided into three groups, gavage 2 ml, aspirin 2 mg and 6 mg at 12 h, 24 h ,48 h, 72 h after ischemia-reperfusion, and conventional feed 72 h. Use hyperglycemia-enhanced hemorrhagic transformation in a rat model of cerebral isehemia. 72 h after brain reperfusion, measured brain blood loss, MMP and Evans blue. Measured the nerve function score and weight of rats at the above four time points. Results （ 1 ） The volume of bleeding,the amount of Evans blue,MMP-2 measured quantity and the comparison of D-value between rat weight in ischemic brain tissue between the three groups of rats had no statistically significant difference. （2）The D-value of 2 mg aspirin group between the neurological function score at 72 h after reperfusion and nerval function score at 12 h compared with controlled group was bigger（P 〈 0.05 ）. Conclusion After 12 h of acute hyperglycemia-enhanced hemorrhagic transformation in a rat model of cerebral ischemia, using aspirin does not increase the blood-brain barrier damage in the early stage. It is good for nerve functional recovery after HT.

关 键 词：阿司匹林 脑梗死出血转化 缺血再灌注 基质金属蛋白酶-2 

分 类 号：R743.34[医药卫生—神经病学与精神病学]