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作 者:李楠[1] 王雪明[1] 张萌[1] 苏丽[1] 朱超慧[1] 李娜[1] 翟俊山[1] 王艳梅[1] 王欣[1]
出 处:《中华临床营养杂志》2014年第6期339-342,共4页Chinese Journal of Clinical Nutrition
基 金:北京市自然科学基金(7132175)
摘 要:目的 探讨肠外营养(PN)及肠内营养(EN)支持对溃疡性结肠炎的效果.方法 本前瞻性研究选取2012年1月至2013年9月本科收治的112例溃疡性结肠炎患者,采用随机数字表法分为PN+ EN组(n=56)及对照组(n=56).两组均接受4周溃肠性结肠炎药物治疗,4周后比较两组的治疗效果及治疗前后的Mayo评分、总蛋白、白蛋白、前白蛋白和体重指数.结果 PN+ EN组营养支持4周后总有效率显著高于对照组(83.93%比48.21%,P=0.00),Mayo评分显著低于对照组(3.11 ±0.46比7.46 ±0.88,P=0.00).与对照组比较,PN+ EN组营养支持后总蛋白[(65.32±6.78) g/L比(59.81 ±6.98) g/L,P=0.00]、白蛋白[(36.20 ±6.89) g/L比(29.20 ±5.79) g/L,P=0.01]、前白蛋白[(267.23±63.48) g/L比(245.38±57.39) g/L,P=0.000]、体质量指数[(23.45±3.02) kg/m2比(21.34±3.07) kg/m2,P=0.04]均显著升高.结论 对溃疡结肠炎患者进行PN+ EN支持可提高临床治疗效果,降低溃疡性结肠炎活动性,并显著改善患者的营养状况.Objective To explore the efficacy of parenteral nutrition (PN) and enteral nutrition (EN) in the treatment of ulcerative colitis.Methods For this prospective study,112 patients with ulcerative colitis from January 2012 to September 2013 in our department were enrolled and divided into PN + EN group (n =56) and control group (n =56,treated with conventional therapy) using a random number table.Both groups received 4 weeks of treatment.After 4 weeks,Mayo scores,total protein,albumin,prealbumin,and body mass index were compared between the 2 groups and with the baseline data (before treatment).Results After treatment,the total effective rate in the PN + EN group was significantly higher than that in the control group (83.93% vs.48.21%,P =0.00),and the Mayo score significantly lower than in the control group (3.11 ± 0.46 vs.7.46 ± 0.88,P =0.00).When compared with the control group,the total protein [(65.32 ± 6.78) g/Lvs.(59.81±6.98) g/L,P=0.00],albumin[(36.20±6.89) g/Lvs.(29.20±5.79) g/L,P =0.01],prealbumin [(267.23 ± 63.48) g/L vs.(245.38 ± 57.39) g/L,P =0.00],and body mass index [(23.45 ± 3.02) kg/m2 vs.(21.34 ± 3.07) kg/m2,P =0.04] in the PN + EN group were significantly increased.Conclusion PN + EN support can enhance the therapeutic effect in patients with ulcerative colitis,reduce the activity of this disease,and significantly improve the nutritional status of the patients.
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