血清水通道蛋白-1在喉癌中的表达及临床病理特征的关系  

Expression of Serum Aquaporins- 1 and the Relationship with Clinicopathological Characteristics in Patients with Laryngeal Carcinoma

作　　者：刘权忠 黄国鹏[2] 

机构地区：[1]重庆市南川区人民医院耳鼻咽喉科,重庆南川408400 [2]重庆医科大学附属第一医院大足医院心内科,重庆大足402360

出　　处：《河北医学》2015年第1期118-122,共5页Hebei Medicine

基　　金：重庆市卫生局医学科研计划资助项目;(编号:2010-2-443)

摘　　要：目的:探讨血清水通道蛋1(AQP1)在喉癌中的表达及其与喉癌临床病理特征的关系。方法:采用酶联免疫吸附法(ELISA)检测82例喉癌患者(喉癌组)和30例健康者(对照组)的AQP1的水平,并结合患者的TNM分期(0期、Ⅰ期、Ⅱ期、Ⅲ期及Ⅳ期)、肿瘤组织学分化程度(高分化、中分化和低分化)、浸润深度(T1、T2、T3、T4期)及淋巴结转(N0、N1及N2)情况进行分析。结果:喉癌血清AQP1水平比健康对照组显著增加(P<0.05);除了浸润深度T1、T2之间无统计学差异(P>0.05),其他不同TNM分期、肿瘤组织学分化程度、浸润深度、淋巴结转患者的血清AQP1水平两两之间差异均有统计学意义(均为P<0.05);喉癌患者AQP1与TMN分期、浸润深度、淋巴结转移具有正相关性(均为P<0.05);与肿瘤组织学分化程度具有负相关性(P<0.05)。结论:喉癌患者血清AQP1水平升高,并且与TMN分期、浸润深度、淋巴结转移及肿瘤组织学分化有关系,有望作为喉癌早期诊断的血清分子标记物。Objective：To explore the expression of serum aquaporins-1（ AQP-1） and the relationship with clinicopathological characteristics in patients with laryngeal carcinoma .Method： The levels of serum aquaporins-1 detected by enzyme-linked immunosorbent assay （ELISA）in 89 patients with laryngeal carci-noma （ laryngeal carcinoma group ） and 30 healthy subjects （ control group ） ,and the TNM staging （ stage 0, stageⅠ, stageⅡ, stageⅢand stageⅣ） , the degree of tumor differentiation （ poor differentiated , moderately differentiated and well differentiated ） , infiltrating depth （ T1, T2, T3, T4） and lymph node metastasis （ N0, N1, and N2） were analyzed.Result：The levels of serum AQP-1 in laryngeal carcinoma group were signifi-cantly elevated,compared with healthy control group （P 〈0.05）, the levels of serum AQP-1 in any two in TNM Staging tumor differentiation , infiltrating depth and lymph node metastasis were very signifficant differ-ence （ P〈0.05） ,except T1 and T2（ P〉0.05） , the levels of serum AQP-1in patients with laryngeal carcino-ma was a positive correlation with TNM staging infiltrating depth or lymph node metastasis （ P 〈0.05） .The levels of serum AQP-1in patients with laryngeal carcinoma was negative correlation with tumor differentiation （P 〈0.05）.Conclusion： The levels of serum AQP-1 in patients with laryngeal is increased.There＆#39;s rela-tionship between serum AQP-1 and TNM staging , infiltrating depth , tumor differentiation or lymph node me-tastasis, The serum AQP-1 levels is expected to become the new serum tumor markers in early diagnosis of laryngeal cancer .

关 键 词：喉癌 水通道蛋白-1 临床病理特征 

分 类 号：R739.65[医药卫生—肿瘤]