中毒性心肌损伤代谢调节药物的应用进展  

Application and progress of metabolism regulators in toxic myocardial injury

作　　者：刘扬[1] 胡英华[1] 丁国华[1] 冯克玉[1] 

机构地区：[1]黑龙江省第二医院暨黑龙江省中毒抢救治疗中心,黑龙江哈尔滨150010

出　　处：《中国工业医学杂志》2014年第6期426-430,共5页Chinese Journal of Industrial Medicine

基　　金：黑龙江省自然科学基金项目"常见特殊解毒药的药动学研究"(编号D201142)

摘　　要：中毒性心肌损伤是由化学物或药物中毒引起的。由于中毒毒物不同,心肌损伤的机制亦不同,在临床治疗上应依据中毒性心肌损伤发生机制和各种毒物的中毒特点,除给予特效解毒剂外,应给予心肌代谢调节药物,特别是改善能量代谢药物、抗氧自由基药物以及中药注射剂等可提供心肌营养、改善心肌代谢、保护心肌细胞,增强和改善心肌功能等,避免中毒性心肌损伤进一步加重或恶性心律失常、心力衰竭、休克、心源性猝死等的发生。Toxic myocardial injury is caused by chemical poisoning or drug overdose, with different mechanisms according to different chemicals, therefore, the clinical detoxication treatment should be based on the toxic mechanism to select specific antidote. Additionally, the myocardial metabolism regulators should also be given, especially the energy metabolism improving drugs, oxygen free radical scavengers and some traditional Chinese medicines, for providing myocardial nutrition, improving myocardial metabolism, protecting myocardial cells, enhancing cardiac function, thereby avoid appearances of myocardial injury aggravation such as malignant arrhythmia, heart failure, shock, or sudden cardiac death.

关 键 词：中毒性 心肌损伤 代谢调节 药物治疗 

分 类 号：R541.9[医药卫生—心血管疾病]