泪腺腺样囊性癌S-100蛋白、神经细丝酸性蛋白的表达及其意义  

Expression and significance of S-100 and GFAP in lacrimal adenoid cystic carcinoma

作　　者：王磊峰[1] 董玉萍[1] 朱素芳[1] 李晓娟[1] 董秋艳[1] 黑砚[2] 

机构地区：[1]武警北京总队第二医院眼科,100037 [2]武警总医院眼眶病研究所,北京100039

出　　处：《武警医学》2014年第12期1252-1255,共4页Medical Journal of the Chinese People's Armed Police Force

摘　　要：目的探讨泪腺腺样囊性癌S-100蛋白及神经细丝酸性蛋白(glial fibrillary acidic protein,GFAP)的表达及其意义。方法收集手术切除泪腺腺样囊性癌28例标本,根据临床症状及组织学观察分为嗜神经侵袭组(15例)和无嗜神经侵袭组(13例),并取术中切除的正常泪腺组织9例为正常对照。应用免疫组织化学SP染色法检测S-100及GFAP在上述组织中表达的差异。结果嗜神经侵袭性生长组的S-100、GFAP阳性表达分别为12例(80%)和9例(60%),与无嗜神经侵袭性生长组S-100阳性5例(41.67%)、GFAP阳性表达率为0相比,呈显著升高趋势,差异有统计学意义(P<0.05)。结论 GFAP、S-100在有嗜神经性侵袭的腺样囊性癌中有特异性表达,其侵袭特性可能与肿瘤细胞中存在着神经膜细胞分化有关。Objective To investigate the expression of Schwann＇s cell markers S-100 and GFAP in lacrimal adenoid cystic carcinoma,and to explore the relationship between GFAP or S-100 expression and neural invasion of adenoid cystic carcinoma.Methods Twenty-eight lacrimal adenoid cystic carcinoma and 9 normal lacrimal gland specimens were collected. Each specimen was stained by S-P（ streptavidin / peroxidase） immuno-histochemical staining. The expression of S-100 and GFAP was analyzed by immunohistochemistry in order to find the difference in the above-mentioned tissues. One-way ANOVA,Student,s test,chi-square test or linear correlation were carried out for statistical evaluation. Results The average S-100 Index（ S-100LI） in nor-neural invasion group and neural invasion group were 0. 62 ± 1. 19 and 16. 73 ± 24. 74,respectively,in lacrimal gland adenoid cystic carcinoma.（ P〈0. 05）.The average GFAP LI in nor-neural invasion group and neural invasion group were 0 and 2. 07 ± 3. 01,respectively,in lacrimal gland adenoid cystic carcinoma.（ P〈0. 05）. Conclusions Schwann＇s cell markers GFAP and S-100 in neural invasion group is higher than that in nor-neural invasion group（ P〈0. 05）. The Schwann＇s cell differentiation may account histologically for the neural invasion of lacrimal gland adenoid cystic carcinoma.

关 键 词：泪腺腺样囊性癌 S-100 神经细丝酸性蛋白 嗜神经性 免疫组织化学 

分 类 号：R777.5[医药卫生—眼科]