食管鳞状细胞癌组织中GASC1蛋白的表达及意义  

Expression of GASC1 protein in esophageal squamous cell carcinoma tissue

作　　者：李娜[1] 杨薇 王新帅[1] 孙佳春[1] 孔国强[1] 单探幽[1] 贾瑞诺[1] 原翔 刘刚[1] 高社干[1] 

机构地区：[1]河南科技大学第一附属医院肿瘤中心,洛阳471003 [2]国家电网许继集团,许昌461000

出　　处：《郑州大学学报（医学版）》2014年第5期608-611,共4页Journal of Zhengzhou University(Medical Sciences)

基　　金：河南省卫生厅重大项目201001008;河南省科技攻关重大项目112300410314

摘　　要：目的:探讨鳞癌扩增基因1(GASC1)在食管鳞状细胞癌(ESCC)组织中的表达及临床意义。方法:采用免疫组化SP法检测82例ESCC组织及相应癌旁正常食管黏膜组织(距离癌组织5 cm以上)中GASC1的表达;术后随访2 a,对GASC1阴性和阳性表达的ESCC患者进行生存分析。结果:ESCC和配对癌旁正常食管黏膜组织中GASC1蛋白的阳性表达率分别为51.2%、42.7%,两种组织中GASC1蛋白的阳性表达率差异无统计学意义(χ2=1.895,P=0.169),但具有一致性(Kappa=0.538,P<0.001)。在T3期、中低分化、有淋巴结转移和临床晚期(Ⅲ期)等恶性程度较高的ESCC组织中GASC1蛋白阳性表达率高于T1及T2期、高分化、无淋巴结转移和临床早期(Ⅰ、Ⅱ期)者(χ2=5.030、6.057、8.995、7.045,P<0.05)。GASC1阳性组和阴性组ESCC患者术后2 a KaplanMeier生存曲线差异有统计学意义(χ2=5.688,P=0.040),2 a生存率分别为65.8%和86.4%。结论:GASC1表达与ESCC恶性表型、侵袭能力及预后有关。Aim：To detect the expression of gene amplified in squamous cell carcinoma 1（ GASC1） protein in esopha-geal squamous cell carcinoma （ ESCC） tissue.Methods：A total of 82 primary ESCC specimens and adjacent normal muco-sa tissue were collected to examine the GASC 1 expression by immunohistochemistry .The patients obtained two-year follow-up,and Kaplan-Meier survival analysis was conducted .Results：GASC1 positive expression rate was 51.2%in ESCC tissue and 42.7%in adjacent normal mucosa tissue,there were no difference（χ^2 =1.895,P=0.169）,but consistency between ESCC and adjacent normal mucosa tissue（Kappa=0.538,P〈0.001）.GASC1 expression was higher in tissues with T3, median and low degree of differentiation ,lymph node metastasis and at clinical Ⅲ stage than those in tissues with T 1 and T2,high degree of differentiation ,no lymph node metastasis and at clinical ⅠandⅡstage （χ^2 =5.030,6.057,8.995, 7.045,P〈0.05）.The Kaplan-Meier survival curves of patients with GASC1 positive expression and with GASC1 negative expression had significant difference （χ^2 =5.688,P=0.040）,the two-year survival rate was 65.8% and 86.4%,respec-tively.Conc lusion：GASC1 may be associated with esophageal malignant phenotype ,invasive ability and prognosis .

关 键 词：食管鳞状细胞癌 鳞癌扩增基因1 预后 

分 类 号：R735.1[医药卫生—肿瘤]