阿托伐他汀对急性脑梗死患者血清内脂素、超敏C反应蛋白及一氧化氮水平的影响  

Influence of atorvastatin on serum visfatin,high-sensitivity C-reactive protein and nitric oxide in patients with acute cerebral infarction

作　　者：余艳华[1] 李军荣[1] 侯卓然 

机构地区：[1]南京医科大学附属江宁医院神经内科,江苏南京211123

出　　处：《实用临床医药杂志》2014年第23期5-7,共3页Journal of Clinical Medicine in Practice

基　　金：中国高校医学期刊临床专项资金项目(11321348)

摘　　要：目的观察阿托伐他汀对急性脑梗死(ACI)患者血清内脂素、超敏C反应蛋白(hs-CRP)及一氧化氮(NO)水平的影响。方法选取ACI患者70例,随机分为观察组33例和对照组37例,观察组在对照组常规治疗基础上加用阿托伐他汀。观察2组总有效率、卒中量表评分以及血清内脂素、HS-CRP及NO水平变化。结果观察组总有效率为90.91%,显著高于对照组的72.22%;治疗后2组卒中量表评分、血清内脂素、hs-CRP均较治疗前显著下降(P<0.01),且观察组显著低于对照组(P<0.01);NO水平较治疗前显著升高(P<0.01),且观察组显著高于对照组(P<0.01)。结论常规治疗联合阿托伐他汀治疗ACI,可有效降低血清内脂素、hs-CRP水平,升高NO水平。Objective To explore the influence of atorvastatin on serum visfatin,high-sensitivity C-reactive protein （hs-CRP） and nitric oxide （NO） in patients with acute cerebral infarction （ACI）.Methods A total of 70 ACI patients were randomly divided into control group （33 cases） treated with routine treatment and observation group （37 cases） added with atorvastatin.Total response rate （RR） and stroke scale as well as the level changes of serum visfatin,hs-CRP and NO in both groups were observed.Results The total RR was 90.91% in observation group,evidently higher than the 72.22 % in control group.After treatment,the stroke scale,serum visfatin and hs -CRP decreased obviously in both groups （P 〈 0.01）,which were markedly lower in observation group than in control group （P〈0.01）.In addition,NO level increased apparently after treatment than treatment before （P 〈 0.01）,and was significantly higher in observation group than in control group （P 〈 O.01）.Conclusion Routine treatment concomitant with atorvastatin can effectively reduce the levels of serum visfatin,hs-CRP and NO in ACI patients.

关 键 词：急性脑梗死 神经功能 阿托伐他汀 内脂素 超敏C反应蛋白 一氧化氮 

分 类 号：R743[医药卫生—神经病学与精神病学]