VEGF和PTEN蛋白在前列腺癌组织中的表达及意义  

Expressions and significances of VEGF and PTEN in tissues of patients with prostate cancer

作　　者：石鹏[1] 张一兵[1] 刘志飞[2] 霍炳越 李红民[3] 张洁[3] 

机构地区：[1]河北联合大学基础医学院,河北唐山063009 [2]河北省唐山市人民医院泌尿二科,河北唐山063001 [3]河北省唐山市人民医院病理科,河北唐山063001

出　　处：《实用临床医药杂志》2014年第23期32-34,共3页Journal of Clinical Medicine in Practice

基　　金：中国高校医学期刊临床专项资金(11321450)

摘　　要：目的探讨血管内皮生长因子(VEGF)与张力蛋白同源第10号染色体缺失的磷酸酶(PTEN)蛋白在前列腺癌组织中的表达及其临床意义。方法选取前列腺癌组织标本56例作前列腺癌组,前列腺结节性增生组织标本30例作对照组,检测2组PTEN和VEGF的阳性表达率,并分析两者相关性。结果前列腺癌组VEGF蛋白阳性表达率显著升高(P<0.01),而PTEN蛋白阳性表达率显著降低(P<0.01)。VEGF表达随TNM分期的增加而增加(P<0.05),随肿瘤分化程度降低而升高(P<0.05);PTEN表达随TNM分期的增加而降低(P<0.05),高分化组表达量高于中、低分化组(P<0.05)。VEGF与PTEN蛋白显著负相关(r=-0.543,P<0.05)。结论前列腺癌组织中PTEN蛋白表达下调,VEGF表达上调,两者联合检测有助于评估病情及预后。Objective To explore the expressions and significances of vascular endothelial growth factor （VEGF） and phosphatase and tensin homolog deleted on chromosome ten （PTEN） in tissues of prostate cancer （PCa）.Methods A total of 56 tissue samples from PCa patients served as PCa group,while other 30 tissue samples from patients with benign prostatic hyperplasia were selected as control group.The positive rates of VEGF and PTEN of two groups were detected and their relationship was analyzed.Results The positive rate VEGF increased evidently （P 〈 0.01） while the rate of PTEN decreased apparently in PCa group （P 〈 0.01）.VEGF expression increased along with the increase of TNM staging and tumor differentiation degree （P 〈 0.05） while PTEN decreased along with the increase of TNM staging,and it expressed obviously higher in high-differentiation group than in moderate-and low-differentiation group （P 〈 0.05）.In addition,VEGF expression was in negative association with the expression of PTEN expression （r =-0.543,P〈0.05）.Conclusion The expression of PTEN protein down-regulates while that of VEGF up-regulates in patients with PCa,whose combined detection is of great benefit for the evaluation and prognosis of PCa.

关 键 词：前列腺癌 血管内皮生长因子 张力蛋白同源第10号染色体缺失的磷酸酶 免疫组织化学 

分 类 号：R737.25[医药卫生—肿瘤]