腹腔镜手术治疗子宫内膜癌的临床观察及癌组织中Bcl-2、Ki-67的表达  

Clinical observation of endometrial cancer treated by laparoscopic surgery and the expressions of Bcl-2 and Ki-67 in cancerous tissue

作　　者：郭芳芳[1] 邢洪存[2] 王晶[1] 刘丽颖[1] 

机构地区：[1]吉林省肿瘤医院妇瘤二科 [2]吉林省长春市中心医院肿瘤科,吉林长春132000

出　　处：《实用临床医药杂志》2014年第23期67-69,76,共4页Journal of Clinical Medicine in Practice

基　　金：中国高校医学期刊临床专项资金(11321471)

摘　　要：目的观察腹腔镜手术治疗子宫内膜癌的临床疗效及癌组织中Bcl-2、Ki-67的表达。方法将84例子宫内膜癌患者随机分为2组,腹腔镜组进行腹腔镜广泛子宫切除联合双附件切除术,开腹组进行腹式广泛子宫切除联合双附件切除术。结果腹腔镜组术中出血量、肠道功能恢复时间及术后住院时间均显著少于开腹组,而手术时间较开腹组明显增加,差异均有统计学意义(P<0.01)。腹腔镜组术后Bcl-2阳性表达率(51.1%)及术后以Ki-67为代表的细胞增殖指数PI[(28.09±15.60)%]与开腹组比较无显著差异(P>0.05)。结论腹腔镜手术治疗子宫内膜癌具有损伤小、术后恢复快等优点,但在常规手术时间内并不影响子宫内膜Bcl-2、Ki-67的表达。Objective To explore the clinical efficacy of laparoscopic surgery in treatment of endometrial cancer and to observe the expressions of Bcl-2 and Ki-67 in cancerous tissue.Methods Totally 84 endometrial cancer patients were randomly divided into 2 groups.Laparoscopic group received laparoscopic radical hysterectomy and bilateral adnexectomy while laparotomy group was treated with abdominal radical hysterectomy and bilateral adnexectomy.Results The amount of bleeding,intestinal function recovery time and postoperation hospitalization duration of laparoscopic group were all significantly lower than those of laparotomy group （P 〈 0.01）,while the operative time was remarkably longer than that of laparotomy group （P〈0.01）.The expression level of Bcl -2 （51.1%） and the Ki-67 represented in proliferation index （PI） [（28.09 ± 15.60） %] of laparoscopic group were not different from those of laparotomy group （P 〉 0.05）.Conclusion Laparoscopic surgery has benefits of small trauma and faster recovery in treatment of endometrial cancer patients and does not affect expressions of Bcl-2 and Ki-67 during conventional surgery time

关 键 词：腹腔镜手术 子宫内膜癌 BCL-2 KI-67 

分 类 号：R737.33[医药卫生—肿瘤]