莫沙必利联合不同胃酸分泌抑制剂对反流性食管炎的影响  

The effect of Mosapride combined with different gastric acid secretion inhibition on reflux esophagitis

作　　者：雷志群[1] 毛乙鸿 

机构地区：[1]合江县人民医院,四川合江646200

出　　处：《基层医学论坛》2014年第34期4616-4618,共3页The Medical Forum

摘　　要：目的探讨莫沙必利联合不同胃酸分泌抑制剂类药物对反流性食管炎(RE)的影响。方法将116例RE患者随机分为治疗组和对照组,治疗组给予莫沙必利片+泮托拉唑肠溶胶囊,对照组予莫沙必利片+法莫替丁,观察2组患者症状改善、消失时间以及临床疗效。结果治疗组症状改善时间和消失时间均明显短于对照组(P<0.01),症状和胃镜下显效率均优于对照组,差异均有统计学意义(P<0.05)。结论胃肠动力药莫沙比利联合质子泵抑制剂药物泮托拉唑对RE的作用强于联合H2受体拮抗剂类药物法莫替丁。Objective To investigate the effect of Mosapride combined with different gastric acid secretion inhibitors on reflux esophagitis （RE）. Methods 116 cases of RE were randomly divided into treatment group and control group, treatment group was treated with Mosapride ＋ Pantoprazole, the control group was given Mosapride ＋ Famotidine, symptoms improved and disappeared time and clinical effect of two groups were observed. Results In treatment group, the time of symptoms improved and disappeared was shorter than the control group （P〈0.01）, clinical symptoms effect and endoscopic effect was better than the control group,The difference between two groups was significant （P〈0.05）.Conclusion The effect of gastrointestinal motility Mosapride combined with proton pump inhibitor Pantoprazole was stronger on RE than combined with H2 receptor antagonists＇ Famotidine.

关 键 词：反流性食管炎 莫沙比利 泮托拉唑 法莫替丁 疗效对比 

分 类 号：R571[医药卫生—消化系统]