糖皮质激素受体α对预测多发性硬化患者激素反应性的价值  

The value of glucocorticoid receptorαin predicting steroid response in patients with multiple sclerosis

作　　者：郝溥辰[1] 张星虎[1] 

机构地区：[1]首都医科大学附属北京天坛医院神经内科,100050

出　　处：《中国神经免疫学和神经病学杂志》2015年第1期9-11,共3页Chinese Journal of Neuroimmunology and Neurology

基　　金：教育部神经病学重点学科;国家高技术研究发展计划(863计划)资助项目(2007AA02Z453)

摘　　要：目的探讨糖皮质激素受体α(glucocorticoid receptorα,GRα)对预测多发性硬化(multiple sclerosis,MS)患者激素反应性的价值。方法使用ELISA法检测19例MS患者外周血单个核细胞(peripheral blood mononuclear cell,PBMC)中平均GRα浓度;于治疗前、治疗后28d对患者行扩展残疾状况评分量表(expanded disability status scale,EDSS)评分;测定7例患者的半抑制浓度(half maximal inhibitory concentration of a substance,IC50)并与19名健康对照进行比较。结果治疗有效组MS患者平均GRα浓度显著高于治疗无效组〔(131.94±76.28)ng/106细胞vs.(56.98±25.28)ng/106细胞,P<0.05〕。MS患者治疗前平均GRα浓度与IC50间呈负相关(r=-0.826,P<0.05)。结论 GRα对MS患者的激素反应性存在一定预测价值,可能成为预测MS患者激素反应性的新指标。Objective To study the value of glucocorticoid receptor（GRα）in predicting steroid response in patients with multiple sclerosis（MS）.Methods GRαin peripheral blood mononuclear cell（PBMC）of 19 MS patients was detected by ELISA.Expanded disability status scale（EDSS）score was evaluated before and 28 days after treatment.IC50 of 7 MS patients and control group were detected before treatment.Results The average concentration of GRαin MS patients whose treatment was effective was higher than the rest of MS patients[（131.94±76.28）ng/10^6 cells vs.（56.98±25.28）ng/10^6 cells,P〈0.05].The average concentration of GRαand IC50 had a negative correlation,the Pearson correlation coefficient was-0.826,P = 0.022.Conclusions Detecting the average concentration of GRαmay be a new method to predict the steroid response of MS patients.

关 键 词：多发性硬化 糖皮质激素受体 激素反应性 IC50 EDSS评分 

分 类 号：R744.52[医药卫生—神经病学与精神病学] R544.1[医药卫生—临床医学]